D4434

Dichloromethylenediphosphonic acid disodium salt

• Synonym(s): Cl₂MDP, Clodronate disodium, Clodronic acid disodium salt, DMDP
• Linear Formula: CH₂O₆Cl₂Na₂P₂
• CAS Number: 22560-50-5
• Molecular Weight: 288.86
• Número de EC: 245-078-9
• Número MDL: MFCD01632786
• ID de la sustancia en PubChem: 24278371

Properties

• formulario: powder
• Nivel de calidad: 300
• solubilidad: water: 49.00-51.00 mg/mL, clear, colorless
• temp. de almacenamiento: room temp
• SMILES string: [Na+].[Na+].OP([O-])(=O)C(Cl)(Cl)P(O)([O-])=O
• InChI: 1S/CH4Cl2O6P2.2Na/c2-1(3,10(4,5)6)11(7,8)9;;/h(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
• InChI key: HJKBJIYDJLVSAO-UHFFFAOYSA-L
• Gene Information: rat ... Man2a1(25478) , Si(497756)

Description

Acciones bioquímicas o fisiológicas

Analog of pyrophosphate ion that inhibits the osteoclastic activity leading to bone resorption and osteoporosis. The compound is used in cancer research, especially in skeletal metastases and breast carcinoma. When entrapped in liposomes, it is used for macrophage-selective depletion (macrophage "suicide" technique), especially in spleen and liver. Found also to inhibit collagenase and matrix metalloproteinase1.

Safety Information

• Código de clase de almacenamiento: 13 - Non Combustible Solids
• WGK: WGK 3
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)