D8941

2,6-Difluoro-4-[2-(phenylsulfonylamino)ethylthio]phenoxyacetamide

Name: 2,6-Difluoro-4-[2-(phenylsulfonylamino)ethylthio]phenoxyacetamide
Brand: SIGMA

≥98% (HPLC), solid

Sinónimos:

PEPA

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Fórmula empírica (notación de Hill):

C₁₆H₁₆N₂O₄S₂F₂

Número CAS:

141286-78-4

Peso molecular:

402.44

Número MDL:

MFCD04974493

Código UNSPSC:

12352200

ID de la sustancia en PubChem:

24278571

NACRES:

NA.77

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Ensayo

≥98% (HPLC)

Formulario

solid

condiciones de almacenamiento

protect from light

color

white

solubilidad

DMSO: >20 mg/mL

cadena SMILES

NC(=O)COc1c(F)cc(SCCNS(=O)(=O)c2ccccc2)cc1F

InChI

1S/C16H16F2N2O4S2/c17-13-8-11(9-14(18)16(13)24-10-15(19)21)25-7-6-20-26(22,23)12-4-2-1-3-5-12/h1-5,8-9,20H,6-7,10H2,(H2,19,21)

Clave InChI

GTACSIONMHMRPD-UHFFFAOYSA-N

Información sobre el gen

human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)

Categorías relacionadas

Agonistas bioactivos de moléculas pequeñas

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Este artículo	P6124	SML1612	S5696
Sigma-Aldrich D8941 2,6-Difluoro-4-[2-(phenylsulfonylamino)ethylthio]phenoxyacetamide	Sigma-Aldrich P6124 5-(4-Phenoxybutoxy)psoralen	Sigma-Aldrich SML1612 2-PMPA	Sigma-Aldrich S5696 SKI II
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form solid	form solid	form powder	form solid
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
solubility DMSO: >20 mg/mL	solubility DMSO: 9 mg/mL	solubility H₂O: 20 mg/mL, clear	solubility DMSO: ≥20 mg/mL
storage condition protect from light	storage condition protect from light	storage condition desiccated	storage condition protect from light
color white	color white	color white to beige	color off-white

Acciones bioquímicas o fisiológicas

2,6-Difluoro-4-[2-(phenylsulfonylamino)ethylthio]phenoxyacetamide is a structurally novel, selective, high affinity AMPA ionotropic glutamate receptor agonist that reduces ischemia-induced performance deficits in rats.

2,6-Difluoro-4-[2-(phenylsulfonylamino)ethylthio]phenoxyacetamide is a structurally novel, selective, high affinity AMPA ionotropic glutamate receptor agonist.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number

128K4718

102K4707

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Giardia lamblia Decreases NF-κB p65RelA Protein Levels and Modulates LPS-Induced Pro-Inflammatory Response in Macrophages.

Clarissa Perez Faria et al.

Scientific reports, 10(1), 6234-6234 (2020-04-12)

The protozoan Giardia lamblia is the most common cause of parasitic gastrointestinal infection worldwide. The parasite developed sophisticated, yet not completely disclosed, mechanisms to escape immune system and growth in the intestine. To further understand the interaction of G. lamblia

Reinforcement of Epoxy Composites with Application of Finely-ground Ochre and Electrophysical Method of the Composition Modification.

Amirbek Bekeshev et al.

Polymers, 12(7) (2020-07-02)

The conducted studies have proven the possibility of the directed control of operational properties of epoxy composites, due to the addition of finely-ground ocher into their composition, and the use of microwave modification of the epoxy composition. The rational content

Activation of AMPA receptor in the infralimbic cortex facilitates extinction and attenuates the heroin-seeking behavior in rats.

Weisheng Chen et al.

Neuroscience letters, 612, 126-131 (2015-12-08)

Infralimbic cortex (IL) is proposed to suppress cocaine seeking after extinction, but whether the IL regulates the extinction and reinstatement of heroin-seeking behavior is unknown. To address this issue, the male SD rats were trained to self-administer heroin under a

Positive modulation of AMPA receptors prevents downregulation of GluR2 expression and activates the Lyn-ERK1/2-CREB signaling in rat brain ischemia.

Quan-Guang Zhang et al.

Hippocampus, 20(1), 65-77 (2009-03-31)

alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are responsible for excitotoxicity induced by ischemic injury in hippocampal CA1 neurons, whereas the molecular mechanisms responsible for their neurotrophic activities are much less studied. Here, we examined the neuroprotective effect of positive modeulation of AMPARs

Manipulating the mussel-inspired co-deposition of tannic acid and amine for fabrication of nanofiltration membranes with an enhanced separation performance.

Yanchao Xu et al.

Journal of colloid and interface science, 565, 23-34 (2020-01-14)

Nanofiltration (NF) membranes with tannic acid (TA) based selective layers have been intensively studied in recent years, but they still suffer from poor inorganic salt rejection. This study provided a first report on mussel-inspired co-deposition of TA and amine to

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2,6-Difluoro-4-[2-(phenylsulfonylamino)ethylthio]phenoxyacetamide