E4642

(±)-Epinephrine hydrochloride

≥98% (TLC), powder, adrenergic receptor agonist

• Sinónimos: (±)-Adrenalin, 4-(1-Hydroxy-2-[methylamino]ethyl)-1,2-benzenediol hydrochloride
• Fórmula empírica (notación de Hill): C₉H₁₃NO₃ · HCl
• Número CAS: 329-63-5
• Peso molecular: 219.67
• NACRES: NA.77
• PubChem Substance ID: 24278422
• UNSPSC Code: 12352200
• EC Number: 206-346-0
• MDL number: MFCD00050562

Propiedades

• Nombre del producto: (±)-Epinephrine hydrochloride,
• Quality Segment: 200
• solubility: H₂O: 50 mg/mL
• storage temp.: 2-8°C
• SMILES string: OC(CNC)C1=CC=C(O)C(O)=C1.Cl
• InChI: 1S/C9H13NO3.ClH/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;/h2-4,9-13H,5H2,1H3;1H
• InChI key: ATADHKWKHYVBTJ-UHFFFAOYSA-N
• Gene Information: human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155)

Descripción

General description

Epinephrine (adrenalin) is synthesized from norepinephrine (noradrenalin) by the action of the enzyme phenylethanolamine N-methyltransferase. Epinephrine comprises 5%-10% of the total catecholamines in the central nervous system. It is a mixed α/β-adrenergic receptor agonist and stimulates these receptors. Their site of synthesis is adrenal medulla and it travels through the vascular systems. Its breakdown occurs in the central nervous system (CNS), liver and kidney.

Application

(±)-Epinephrine hydrochloride has been used:

• in the induction of renalase expression in Human renal proximal tubular epithelial cells
• in the infusion studies to test its effect on heart rate and eye temperature measurements in bull
• as a medium supplement for the stimulation of endothelial progenitor cells

Biochem/physiol Actions

Adrenergic receptor agonist.

Epinephrine improves systemic pressure during cardiopulmonary resuscitation and is used post cardiac arrest. The levels of epinephrine increases during trauma, sepsis and hypoglycemia resulting in increased cardiac rate and contractility. It is used in the treatment of acute anaphylaxis. Use of epinephrine hydrochloride enables dilation of pupil during intraocular lens (IOL) implantation surgery.

Other Notes

The ratio of +/- adrenaline is not determined.

Información de seguridad

• Pictogramas: GHS06
• Palabra de advertencia: Danger
• Códigos de peligro: H301 + H311,H315,H319,H335
• Indicaciones de precaución: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos diana: Respiratory system
• Clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable
• EPI (equipos de protección individual): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges