Merck
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F4891

Sigma-Aldrich

Anti-Goat/Sheep IgG−FITC antibody, Mouse monoclonal

clone GT-34, purified from hybridoma cell culture

Sinónimos:
Monoclonal Anti-Goat/Sheep IgG
NACRES:
NA.46

Nivel de calidad

200

origen biológico

mouse

conjugado

FITC conjugate

forma del anticuerpo

purified from hybridoma cell culture

antibody product type

secondary antibodies

clon

GT-34, monoclonal

formulario

buffered aqueous solution

species reactivity

bovine, sheep, goat

should not react with

rat, chicken, mouse, horse, feline, pig, canine, guinea pig, rabbit, human

condiciones de almacenamiento

protect from light

technique(s)

dot immunobinding: 1:32
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:20
particle immunofluorescence: 1:32

isotipo

IgG1

enviado en

dry ice

temp. de almacenamiento

−20°C

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Descripción general

Monoclonal Anti-Goat IgG (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. IgG (immunoglobulin G) antibody subtype is a predominant serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids. IgG is found in four subclasses IgG1, IgG2, IgG3 and IgG4. IgG has a monomeric structure.
The antibody reacts with an epitope located on the heavy chain of goat IgG1 and IgG2.

Especificidad

Monoclonal Anti-Goat IgG, FITC Conjugate is immunospecific for goat IgG. The antibody does not react with human, mouse, rat, rabbit, guinea pig, horse, or chicken IgGs.

Aplicación

Biofile 39 Navya load

Acciones bioquímicas o fisiológicas

IgG (immunoglobulin G) antibody provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defense of the neonate against infections. IgG antibody participates in complement fixation and opsonization. Goat antibodies against many analytes are widely used in research as primary antibodies in various assay techniques. Second antibodies are that used to detect goat antibodies may lack specificity for goat immunoglobulins, and in many instances will also recognize other immunoglobulins that appear in the preparation being tested. This results in the need for extensive adsorption of the second antibody. Therefore, using a monoclonal antibody to goat IgG that is devoid of a binding capacity to other species can serve as a useful tool in many applications.

Forma física

Solution in 0.01 M sodium phosphate buffer, pH 7.4, containing 1% inactivated bovine serum albumin and 15 mM sodium azide

Almacenamiento y estabilidad

For continuous use, store at 2-8 °C for a maximum of one month. For extended storage, solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Código de clase de almacenamiento

12 - Non Combustible Liquids

WGK

nwg

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificado de Análisis

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Certificado de origen

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Fichas técnicas

Presupuestos y pedidos

Thomas D Barbour et al.
Kidney international, 89(4), 823-832 (2016-03-01)
C3 glomerulopathy is a complement-mediated renal disease that is frequently associated with abnormalities in regulation of the complement alternative pathway. Mice with deficiency of factor H (Cfh(-/-)), a negative alternative pathway regulator, are an established experimental model of C3 glomerulopathy
Anna L Guildford et al.
Journal of the Royal Society, Interface, 8(58), 641-649 (2010-11-26)
In-stent restenosis is a clinical complication following coronary angioplasty caused by the implantation of the metal device in the atherosclerotic vessel. Histological examination has shown a clear contribution of both inflammatory and smooth muscle cells (SMCs) to the deposition of
Complement activity is regulated in C3 glomerulopathy by IgG-factor H fusion proteins with and without properdin targeting domains.
Gilmore, et al.
Kidney International, 99, 396-404 (2021)
IL-21-induced isotype switching to IgG and IgA by human naive B cells is differentially regulated by IL-4
Avery DT, et al.
Journal of Immunology, 181(3), 1767-1779 (2008)
Daniel Murta et al.
PloS one, 9(11), e113365-e113365 (2014-11-21)
In a previous study we identified active Notch signaling in key cellular events occurring at adult spermatogenesis. In this study, we evaluated the function of Notch signaling in spermatogenesis through the effects of in vivo Notch blockade. Adult CD1 male

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