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Merck

F6879

Ferritin from human spleen

Type V, 10 μg/mL in 0.15 M NaCl, 10 mM Tris, pH 8.0, containing 0.1% sodium azide

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Número CAS:
Número MDL:
Código UNSPSC:
12352202
NACRES:
NA.61

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origen biológico

human spleen

Nivel de calidad

esterilidad

sterile-filtered

tpo

Type V

Formulario

liquid

envase

vial of 2 μg

concentración

10 μg/mL in 0.15 M NaCl, 10 mM Tris, pH 8.0, containing 0.1% sodium azide

Nº de acceso UniProt

temp. de almacenamiento

2-8°C

Información sobre el gen

human ... FTH1(2495), FTL(2512)

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Este artículo
F7879F6754SAB5700943
biological source

human spleen

biological source

horse spleen

biological source

human liver

biological source

rabbit

concentration

10 μg/mL in 0.15 M NaCl, 10 mM Tris, pH 8.0, containing 0.1% sodium azide

concentration

10 mg/mL in 0.15 M NaCl

concentration

10 μg/mL

concentration

0.5 mg/mL

form

liquid

form

liquid

form

liquid

form

liquid

UniProt accession no.

P02792, P02794

UniProt accession no.

P02791

UniProt accession no.

P02792, P02794, Q8N4E7

UniProt accession no.

P02792

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

Gene Information

human ... FTH1(2495), FTL(2512)

Gene Information

horse ... FTL(100051593)

Gene Information

human ... FTH1(2495), FTL(2512), FTMT(94033)

Gene Information

human ... FTL(2512)

Aplicación

Ferritin is an iron storage protein that plays a central role in iron metabolism, and may be elevated in inflammatory or malignant diseases. It has been used in studies as an indicator of body iron supply, but may prove inaccurate in in the presence of chronic inflammation.

Acciones bioquímicas o fisiológicas

A ubiquitous iron storage protein that plays a key role in iron metabolism. It serves as an intracellular iron reserve (particularly in spleen, liver, intestinal mucosa, and bone marrow) and functions in iron detoxification. Studies have shown that ferritin iron incorporation is mediated by a ferroxidase activity associated with ferritin H subunits and a nucleation center associated with ferritin L subunits. Release of iron from ferritin has an essential role in iron-dependent lipid peroxidation and may contribute to free radical-induced cell damage in vivo. Therefore, by binding iron, ferritin may function as an antioxidant.

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Ann Kruger et al.
Nephrology nursing journal : journal of the American Nephrology Nurses' Association, 40(2), 135-139 (2013-06-19)
This study examined whether a change infrequency of administration of erythropoietin-stimulating agent affected hemoglobin levels in patients on peritoneal dialysis. Data were extracted from the Australian Renal Anaemia Management database for the years 2002 and 2008. Less frequent dosing and
Flavia G N Rosado et al.
American journal of clinical pathology, 139(6), 713-727 (2013-05-22)
Hemophagocytic lymphohistiocytosis (HLH) is a frequently fatal and likely underdiagnosed disease involving a final common pathway of hypercytokinemia, which can result in end-organ damage and death. Although an early diagnosis is crucial to decrease mortality, the definitive diagnosis is often
Rachel Collings et al.
The American journal of clinical nutrition, 98(1), 65-81 (2013-05-31)
Absorption factors are required to convert physiologic requirements for iron into Dietary Reference Values, but the absorption from single meals cannot be used to estimate dietary iron absorption. The objective was to conduct a systematic review of iron absorption from
Sebastien Leidgens et al.
The Journal of biological chemistry, 288(24), 17791-17802 (2013-05-04)
The mechanisms through which iron-dependent enzymes receive their metal cofactors are largely unknown. Poly r(C)-binding protein 1 (PCBP1) is an iron chaperone for ferritin; both PCBP1 and its paralog PCBP2 are required for iron delivery to the prolyl hydroxylase that
Sara R Zwart et al.
The American journal of clinical nutrition, 98(1), 217-223 (2013-05-31)
Increases in stored iron and dietary intake of iron during space flight have raised concern about the risk of excess iron and oxidative damage, particularly in bone. The objectives of this study were to perform a comprehensive assessment of iron

Preguntas

1–2 de 2 Preguntas  
  1. Hello, what is the loading factor of this product? Thank you.

    1 respuesta
    1. The amount of iron in this product is not determined.

      ¿Le ha resultado útil?

  2. What is the volume of the ferritin solution in the vial?

    1 respuesta
    1. The product is supplied as a vial of 2 μg. There is 200 μL of a 10 μg/mL solution in the vial.

      ¿Le ha resultado útil?

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