RAB1127

Mouse PAI-1 ELISA Kit

for cell culture supernatants, plasma, and serum samples

• NACRES: NA.32
• UNSPSC Code: 41116158
• Species reactivity: mouse, human
• Storage temp.: −20°C
• Shipped in: wet ice

Propiedades

• species reactivity: mouse, human
• technique(s): ELISA: suitable
• assay range: inter-assay cv: <12%; intra-assay cv: <10%; sensitivity: 80 pg/ml
• shipped in: wet ice
• storage temp.: −20°C

Descripción

General description

This ELISA antibody pair detects mouse and human PAI-1.

The PAI-1 (plasminogen activator inhibitor) gene is localized to human chromosome 7q22.1. Active form of PAI-1 is expressed in the blood and tissues. Platelets harbor both the active and latent forms of PAI-1.

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

Biochem/physiol Actions

PAI-1 (plasminogen activator inhibitor) produced by platelets takes part in stabilizing blood clotting mechanism. PAI-1 prevents plasminogen activation during fibrinolysis. This might lead to the risk of cardiovascular disease. Elevated levels of PAI-1 has been observed in type 2 diabetes mellitus and serves the reason for reduced insulin sensitivity. PAI-1 stimulates the process of cellular senescence. PAI-1 regulation occurs through p53 dependent TGF-β (transforming growth factor-β) signalling. Studies also also predict that stress and depression might influence PAI-1 expression.

Other Notes

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

Información de seguridad

• Pictogramas: GHS08
• Palabra de advertencia: Danger
• Códigos de peligro: H334
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable
• Clase de almacenamiento: 10 - Combustible liquids
• Indicaciones de precaución: P261 - P284 - P501
• Hazard Classifications: Resp. Sens. 1