The stability of this product in solution has not been determined. However, pharmaceutical preparations in the form of solutions or ointments appear to be fairly stable when refrigerated. See the link below for a publication that may be helpful:
https://www.cjhp-online.ca/index.php/cjhp/article/view/659.
T4014
Tobramycin
Aminoglycoside antibiotic
Sinónimos:
3′-Deoxykanamycin B, Nebramycin Factor 6, O-[3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)]-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribohexopyranosyl-(1→4)]-2-deoxy-D-streptamine
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| Talla/SKU | Disponibilidad | Precio |
|---|---|---|
100 mg | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 244,00 € |
500 mg | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 845,00 € |
Acerca de este artículo
Fórmula empírica (notación de Hill):
C18H37N5O9
Número CAS:
Peso molecular:
467.51
UNSPSC Code:
51281626
NACRES:
NA.85
PubChem Substance ID:
EC Number:
251-322-5
Beilstein/REAXYS Number:
1357507
MDL number:
244,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Servicio técnico
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Permítanos ayudarlebiological source
Streptomyces tenebrarius
Quality Segment
form
powder
storage condition
(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
concentration
≥900 μg/mg (anhydrous)
color
white to off-white
antibiotic activity spectrum
Gram-negative bacteria
mode of action
protein synthesis | interferes
storage temp.
2-8°C
SMILES string
NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O
InChI
1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11+,12+,13+,14-,15+,16-,17+,18+/m0/s1
InChI key
NLVFBUXFDBBNBW-SNGYORCQSA-N
General description
Tobramycin is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the Pseudomonas species.
Chemical structure: aminoglycoside
Application
Biochem/physiol Actions
Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial membranes by binding to 16S rRNA (ribosomal RNA). It inhibits translocation and elicits miscoding.
Tobramycin is used to treat Pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis, and other soft-tissue infections. It is a potential therapy for sinus infections.
Tobramycin is used to treat Pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis, and other soft-tissue infections. It is a potential therapy for sinus infections.
Tobramycin is an aminoglycoside.
Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding.
Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.
Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding.
Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
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Este artículo | |||
|---|---|---|---|
| description Aminoglycoside antibiotic | description European Pharmacopoeia (EP) Reference Standard | description British Pharmacopoeia (BP) Reference Standard | description European Pharmacopoeia (EP) Reference Standard |
| mode of action protein synthesis | interferes | mode of action - | mode of action - | mode of action - |
| antibiotic activity spectrum Gram-negative bacteria | antibiotic activity spectrum - | antibiotic activity spectrum - | antibiotic activity spectrum - |
| Quality Level 200 | Quality Level - | Quality Level - | Quality Level - |
| form powder | form - | form solid | form - |
| concentration ≥900 μg/mg (anhydrous) | concentration - | concentration - | concentration - |
| biological source Streptomyces tenebrarius | biological source - | biological source - | biological source - |
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signalword
Warning
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Hazard Classifications
Repr. 2
Clase de almacenamiento
11 - Combustible Solids
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What are the recommandations for the storage time and temperature of an aqueous solution of of Tobramycin please?
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