1162400

Dactinomycin

United States Pharmacopeia (USP) Reference Standard

• Sinónimos: Actinomycin D, Actinomycin C₁, Actinomycin IV, Dactinomycin
• Fórmula empírica (notación de Hill): C₆₂H₈₆N₁₂O₁₆
• Número CAS: 50-76-0
• Peso molecular: 1255.42
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329749507
• MDL number: MFCD00005033
• Beilstein/REAXYS Number: 605235

Propiedades

• grade: pharmaceutical primary standard
• agency: USP
• API family: dactinomycin
• manufacturer/tradename: USP
• color: red, powder
• mp: 251-253
• application(s): pharmaceutical; pharmaceutical (small molecule)
• format: neat
• SMILES string: CC(C)[C@H]1NC(=O)[C@@H](NC(=O)c2ccc(C)c3OC4=C(C)C(=O)C(N)=C(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]6CCCN6C(=O)[C@H](NC5=O)C(C)C)C4=Nc23)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]7CCCN7C1=O
• InChI: 1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1
• InChI key: RJURFGZVJUQBHK-IIXSONLDSA-N

Descripción

General description

Find answers to frequently asked questions on USP products in USP FAQs.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dactinomycin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Dactinomycin for Injection

Biochem/physiol Actions

Actinomycin D inhibits the proliferation of cells by forming a stable complex with double-stranded DNA, inhibiting DNA-primed RNA synthesis and causing single-stranded breaks in DNA. It has been shown to be an inhibitor of the minus-strand transfer step in reverse transcriptase.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Información de seguridad

• Pictogramas: GHS06,GHS08
• Palabra de advertencia: Danger
• Códigos de peligro: H300,H350,H360FD
• Indicaciones de precaución: P201 - P202 - P264 - P270 - P280 - P301 + P310
• Hazard Classifications: Acute Tox. 2 Oral - Carc. 1B - Repr. 1B
• Clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable