- DNA gyrase inhibitory activity of ellagic acid derivatives.
DNA gyrase inhibitory activity of ellagic acid derivatives.
Bioorganic & medicinal chemistry letters (1999-01-01)
M A Weinder-Wells, J Altom, J Fernandez, S A Fraga-Spano, J Hilliard, K Ohemeng, J F Barrett
PMID9871636
RESUMEN
Ellagic acid was found to inhibit E. coli DNA gyrase supercoiling with approximately the same potency as nalidixic acid. Tricyclic analogs of ellagic acid, which vary in the number and position of the hydroxy groups as well as their replacement with halogens, have been synthesized. The biological activity of these analogs is discussed.
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