Methyl groups as NMR probes for biomolecular interactions.

Current opinion in structural biology (2015-09-26)
Silke Wiesner, Remco Sprangers
RESUMEN

Intermolecular interactions are indispensible for biological function. Here we discuss how novel NMR techniques can provide unique insights into the assembly, dynamics and regulation of biomolecular complexes. We focus on applications that exploit the methyl TROSY effect and show that methodological advances and biological insights go hand in hand. We envision that future methyl TROSY applications will continue to provide unique information regarding intermolecular interactions, even for very large eukaryotic protein complexes that are often highly asymmetric.

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DLAM-LVproS-13CH3 Methyl Labeling Kit
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SLAM-VproS-13CH3 Methyl Labeling Kit
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SLAM-VproR-13CH3 Methyl Labeling Kit
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DLAM-LVproR-13CH3 Methyl Labeling Kit
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DLAM-Iδ1VproS-13CH3 Methyl Labeling Kit
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DLAM-AβVproS-13CH3 Methyl Labeling Kit
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TLAM-δI1LVproS-13CH3 Methyl Labeling Kit
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TLAM-Iδ1MεTγ-13CH3 Methyl Labeling Kit
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QLAM-Iδ1TγLVproS-13CH3 Methyl Labeling Kit
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QLAM-AβIδ1LVproR-U-13C Methyl Labeling Kit
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SLAM-Aβ-13CHD2 Methyl Labeling Kit
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