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Tris buffer (THAM). An appraisal of its physiologic effects and clinical usefulness.

The New England journal of medicine (1966-04-07)
H L Bleich, W B Schwartz
ABSTRACT

It has been the purpose of this discussion to review critically the physiologic considerations and clinical evidence regarding the use of Tris buffer in the treatment of acid-base disorders. It is concluded that there is little current evidence, theoretical, experimental, or clinical, to support the view that Tris has a significant therapeutic role. Some possible exceptions to this general conclusion are considered.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Trizma® base, BioUltra, for molecular biology, ≥99.8% (T)
Sigma-Aldrich
Trizma® hydrochloride, BioUltra, for molecular biology, ≥99.0% (AT)