[Neuropharmacological potential of sigma1-receptors: new therapeutic possibilities].

Sigma1-receptors are an independent class of intracellular receptors which are implicated in the regulation of cell bioenergetics that suggest their involvement in different neuropsychiatric diseases. Sigma1-receptors regulate different ion channels, including calcium channels, NMDA-receptors, and are involved in the neurotransmitter release, neurogenesis and synaptogenesis. These receptors recognize with a different affinity a variety of ligands of different structural classes with different therapeutic applications. High affinity to sigma1-receptors may play an important role in the mechanism of action of some antidepressants, in particular fluvoxamine.