- Leukemia-specific delivery of mutant NOTCH1 targeted therapy.
Leukemia-specific delivery of mutant NOTCH1 targeted therapy.
The Journal of experimental medicine (2017-11-22)
Giovanni Roti, Jun Qi, Samuel Kitara, Marta Sanchez-Martin, Amy Saur Conway, Anthony C Varca, Angela Su, Lei Wu, Andrew L Kung, Adolfo A Ferrando, James E Bradner, Kimberly Stegmaier
PMID29158376
RESUMEN
On-target drug delivery remains a challenge in cancer precision medicine; it is difficult to deliver a targeted therapy to cancer cells without incurring toxicity to normal tissues. The SERCA (sarco-endoplasmic reticulum Ca
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