Suzuki-Miyaura coupling of NHC-boranes: a new addition to the C-C coupling toolbox.

Organic letters (2009-10-06)
Julien Monot, Malika Makhlouf Brahmi, Shau-Hua Ueng, Carine Robert, Marine Desage-El Murr, Dennis P Curran, Max Malacria, Louis Fensterbank, Emmanuel Lacôte

Complexes of triaryl- and trialkylboranes with N-heterocyclic carbenes (NHCs) participate in Suzuki-Miyaura cross-coupling reactions and provide coupled products in good yields under base-free conditions. The reaction can be applied to Csp(2)-Csp(2) and Csp(2)-Csp(3) carbon-carbon bond formation with triflates, iodides, bromides, and chlorides. These results enrich the utility of NHC-borane complexes, which can be added to the toolkit of Suzuki-Miyaura cross-couplings, along with boronic acids and organotrifluoroborates.

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