SML0737

MitoTEMPO

≥98% (HPLC), powder, antioxidant

• Synonym(s): (2-(2,2,6,6-Tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl)triphenylphosphonium chloride, Mito-TEMPO
• Empirical Formula (Hill Notation): C₂₉H₃₅N₂O₂P · Cl
• CAS Number: 1334850-99-5
• Molecular Weight: 510.03
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Product Name: MitoTEMPO, ≥98% (HPLC)
• SMILES string: [P+](CC(=O)NC4CC(N(C(C4)(C)C)[O])(C)C)(c3ccccc3)(c2ccccc2)c1ccccc1.[Cl-]
• InChI: 1S/C29H34N2O2P.ClH/c1-28(2)20-23(21-29(3,4)31(28)33)30-27(32)22-34(24-14-8-5-9-15-24,25-16-10-6-11-17-25)26-18-12-7-13-19-26;/h5-19,23H,20-22H2,1-4H3;1H
• InChI key: WKKFJIJNGHNQQW-UHFFFAOYSA-N
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated; protect from light
• color: white to light brown
• solubility: H₂O: 10 mg/mL, clear
• storage temp.: −20°C
• Quality Level: 100

Description

Application

MitoTEMPO has been used as a mitochondria-targeted antioxidant.[1][2][3]

Biochem/physiol Actions

MitoTEMPO is a mitochondrially targeted antioxidant, a specific scavenger of mitochondrial superoxide.

MitoTEMPO is a mitochondrially targeted antioxidant, a specific scavenger of mitochondrial superoxide. MitoTEMPO is a combination of the antioxidant piperidine nitroxide TEMPO with the lipophilic cation triphenylphosphonium, giving MitoTEMPO the ability to pass through lipid bilayers with ease and accumulate several hundred-fold in mitochondria. Mitochondrial dysfunction and oxidative stress contribute to a variety of disorders involving cardiovascular, kidney, liver disorders, Parkinson′s and Alzheimer′s disease.

Other Notes

Light sensitive

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable