SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
Synonymes:
EL2, HPP, HS3, SPH3, SPTA
Espèce(s):
Human SPTA1 (6708), Mouse Spta1 (20739), Rat Spta1 (289257), domestic cat SPTA1 (101097298), dog SPTA1 (488616), sheep SPTA1 (101112688), cow SPTA1 (505122), Horse SPTA1 (100056575), naked mole-rat Spta1 (101706547), domestic guinea pig Spta1 (100722803)
ID UniProtKB:
ID du gène:
- Human(6708) Summary: Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq, Jul 2008]
- Mouse(20739) spectrin alpha, erythrocytic 1
- Rat(289257) spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
- domestic cat(101097298) spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
- dog(488616) spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
- sheep(101112688) spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
- cow(505122) spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
- Horse(100056575) spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
- naked mole-rat(101706547) spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
- domestic guinea pig(100722803) spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
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Antibodies
Numéro du produit
Description
Espèces réactives
Application
Spectrin (RBC2/3D5) Mouse Monoclonal Antibody, ,
Espèces réactives
human
Application
immunohistochemistry
Anti-SPTA1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
Anti-SPTA1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
Anti-alpha 1 Spectrin Antibody, clone 1U5K4, Rabbit Monoclonal, ,
Espèces réactives
human, rat
Application
western blot
Anti-SPTA1 antibody produced in rabbit, ,
Espèces réactives
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Proteins
Numéro du produit
Description
Espèce(s)
esiRNA
Numéro du produit
Description
Espèce(s)