07-374

Anti-phospho-KDR/Flk-1/VEGFR2 (Tyr1214) Antibody

Name: Anti-phospho-KDR/Flk-1/VEGFR2 (Tyr1214) Antibody
Brand: MM
Price: 318 GBP
Availability: InStock

Upstate^®, from rabbit

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200 μG

£318.00

Estimated to ship on01 December 2025Details

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

Key Documents

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biological source

rabbit

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, human

manufacturer/tradename

Upstate^®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NM_002253

UniProt accession no.

P35968

shipped in

dry ice

target post-translational modification

phosphorylation (pTyr1214)

Gene Information

human ... KDR(3791)

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This Item	07-819	04-894	07-278
Sigma-Aldrich 07-374 Anti-phospho-KDR/Flk-1/VEGFR2 (Tyr1214) Antibody	Sigma-Aldrich 07-819 Anti-phospho-EGFR (Tyr1148) Antibody	Sigma-Aldrich 04-894 Anti-phospho-KDR/Flk-1/VEGFR2 (Tyr1054) Antibody, clone D1W, rabbit monoclonal	Sigma-Aldrich 07-278 Anti-phospho-LAT (Tyr191) Antibody
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
clone polyclonal	clone polyclonal	clone D1W, monoclonal	clone polyclonal
species reactivity mouse, human	species reactivity human	species reactivity mouse, human	species reactivity human, mouse
antibody form purified antibody	antibody form affinity isolated antibody	antibody form culture supernatant	antibody form purified antibody
shipped in dry ice	shipped in dry ice	shipped in dry ice	shipped in dry ice
UniProt accession no. P35968	UniProt accession no. P00533	UniProt accession no. P35968	UniProt accession no. O43561

General description

200-230 kDa

Immunogen

(...FHpYDN...) in which pY corresponds to phosphorylated tyrosine at residue 1214 of human KDR/VEGFR2. Tyr1214 of human KDR corresponds to Tyr1212 in the mouse protein.

Application

Anti-phospho-KDR/Flk-1/VEGFR2 (Tyr1214) Antibody detects level of phospho-KDR/Flk-1/VEGFR2 (Tyr1214) & has been published & validated for use in WB.

Research Category
Signaling

Research Sub Category
Growth Factors & Receptors

Biochem/physiol Actions

phospho-KDR/VEGFR2 (Tyr1214)

Physical form

0.1M Tris-glycine, pH 7.4, 0.15M NaCl,0.05% sodium azide before the addition of glycerol to 30%

Format: Purified

Protein A purified

Preparation Note

2 years at -20°C

Analysis Note

routinely evaluated by immunoblot RIPA lysates from porcine aortic endothelial cells expressing human CSF-1R/murineVEGFR-2 chimera

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Identification of tyrosine residues in vascular endothelial growth factor receptor-2/FLK-1 involved in activation of phosphatidylinositol 3-kinase and cell proliferation.

V Dayanir et al.

The Journal of biological chemistry, 276(21), 17686-17692 (2001-03-30)

Activation of vascular endothelial growth factor receptor-2 (VEGFR-2) plays a critical role in vasculogenesis and angiogenesis. However, the mechanism by which VEGFR-2 activation elicits these cellular events is not fully understood. We recently constructed a chimeric receptor containing the extracellular

Substitution of C-terminus of VEGFR-2 with VEGFR-1 promotes VEGFR-1 activation and endothelial cell proliferation.

Meyer, Rosana D, et al.

Oncogene, 23, 5523-5531 (2004)

Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor.

Albert, DH; Tapang, P; Magoc, TJ; Pease, LJ; Reuter, DR; Wei, RQ; Li, J; Guo, J; Bousquet et al.

Molecular Cancer Therapeutics null

Phosphorylation of Akt and ERK1/2 is required for VEGF-A/VEGFR2-induced proliferation and migration of lymphatic endothelium.

Dellinger, MT; Brekken, RA

Testing null

A systems pathology model for predicting overall survival in patients with refractory, advanced non-small-cell lung cancer treated with gefitinib.

Michael J Donovan et al.

European journal of cancer (Oxford, England : 1990), 45(8), 1518-1526 (2009-03-11)

To identify clinical and biometric features associated with overall survival of patients with advanced refractory non-small-cell lung cancer (NSCLC) treated with gefitinib. One hundred and nine diagnostic NSCLC samples were analysed for EGFR mutation status, EGFR immunohistochemistry, histologic morphometry and

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