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T6399

Sigma-Aldrich

Trichloroacetic acid

ACS reagent, ≥99.0%

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Synonym(s):
TCA
Linear Formula:
Cl3CCOOH
CAS Number:
Molecular Weight:
163.39
Beilstein:
970119
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

grade

ACS reagent

Quality Level

vapor density

<1 (vs air)

vapor pressure

1 mmHg ( 51 °C)

Assay

≥99.0%

impurities

Substances darkened by sulfuric acid, passes test
≤0.01% insoluble matter

ign. residue

≤0.03%

refractive index

n20/D 1.62 (lit.)

bp

196 °C (lit.)

mp

54-58 °C (lit.)

solubility

H2O: 1 g/10 mL

density

1.62 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤0.002%
nitrate (NO3-): ≤0.002%
phosphate (PO43-): ≤5 ppm
sulfate (SO42-): ≤0.02%

cation traces

Fe: ≤0.001%
heavy metals (as Pb): ≤0.002%

storage temp.

2-8°C

SMILES string

OC(=O)C(Cl)(Cl)Cl

InChI

1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)

InChI key

YNJBWRMUSHSURL-UHFFFAOYSA-N

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1 of 4

This Item
T48859123027242
vibrant-m

T6399

Trichloroacetic acid

vibrant-m

T4885

Trichloroacetic acid

vibrant-m

91230

Trichloroacetic acid

vibrant-m

27242

Trichloroacetic acid

assay

≥99.0%

assay

≥99.0% (titration)

assay

≥99.5% (T)

assay

99-100.5% (calc. to the dried substance)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

-

solubility

H2O: 1 g/10 mL

solubility

H2O: 1 g/10 mL

solubility

water: soluble 81.7 g/L at 20 °C

solubility

soluble 81.7 g/L at 20 °C (completely)

mp

54-58 °C (lit.)

mp

54-58 °C (lit.)

mp

54-58 °C (lit.)

mp

54-58 °C (lit.)

Application

  • Trichloroacetic acid has been used for the precipitation of sLRP (soluble circulating low density lipoprotein receptor-related protein-1) isolated from plasma.
  • It has been used for the extraction of ascorbic acid from plant samples. It has also been used for the preparation of ascorbate standards for ascorbate assay.
  • It has been used for the precipitation of IMAC (immobilized metal ion affinity chromatography)-isolated phosphoproteins.
Traditionally used to precipitate protein. Has been used to determine protein concentration by quantitative precipitation. Used as decalcifier and fixative in microscopy.

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Description
Pricing

Pictograms

CorrosionEnvironment

Signal Word

Danger

Hazard Statements

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A

Storage Class Code

8B - Non-combustible, corrosive hazardous materials

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Trichloroacetic acid puriss. p.a., ACS reagent, &#8805;99.5%

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Casein Kinase 2 (CK2)-mediated Phosphorylation of Hsp90? as a Novel Mechanism of Rifampin-induced MDR1 Expression.
Kim SW et al.
The Journal of Biological Chemistry, 290, 17029-17029 (2015)
Measurement of reduced, oxidized and total ascorbate content in plants.
Gillespie KM and Ainsworth EA
Nature Protocols, 2, 871-871 (2007)
Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-? is an early biomarker for mild cognitive impairment preceding Alzheimer's disease.
Sagare AP et al.
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Increased levels of total tau (t-tau) and hyperphosphorylated tau (p-tau) proteins in the cerebrospinal fluid of Alzheimer's disease (AD) patients are well documented and strongly correlate with AD pathology. Recent studies have further shown that human tau can be released
Philip D Campbell et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(44), 14717-14732 (2014-10-31)
Mutations in Kinesin proteins (Kifs) are linked to various neurological diseases, but the specific and redundant functions of the vertebrate Kifs are incompletely understood. For example, Kif5A, but not other Kinesin-1 heavy-chain family members, is implicated in Charcot-Marie-Tooth disease (CMT)

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