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Y0001008

Citalopram hydrobromide

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide

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5 MG

£124.00

£124.00

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About This Item

Empirical Formula (Hill Notation):
C20H21FN2O · HBr
CAS Number:
59729-32-7
Molecular Weight:
405.30
MDL number:
MFCD02101306
UNSPSC Code:
41116107
PubChem Substance ID:
329831217
NACRES:
NA.24

Key Documents

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grade

pharmaceutical primary standard

API family

citalopram

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Br[H].CN(C)CCCC1(OCc2cc(ccc12)C#N)c3ccc(F)cc3

InChI

1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H

InChI key

WIHMBLDNRMIGDW-UHFFFAOYSA-N

Gene Information

human ... SLC6A4(6532)

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1 of 4

This Item
1134233BP1153PHR1640
Citalopram hydrobromide European Pharmacopoeia (EP) Reference Standard

Y0001008

Citalopram hydrobromide

Citalopram hydrobromide United States Pharmacopeia (USP) Reference Standard

USP

1134233

Citalopram hydrobromide

Citalopram hydrobromide British Pharmacopoeia (BP) Reference Standard

BP1153

Citalopram hydrobromide

Citalopram Hydrobromide Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1640

Citalopram Hydrobromide

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

certified reference material, pharmaceutical secondary standard

manufacturer/tradename

EDQM

manufacturer/tradename

USP

manufacturer/tradename

BP

manufacturer/tradename

-

format

neat

format

neat

format

neat

format

neat

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical
pharmaceutical small molecule

application(s)

pharmaceutical (small molecule)

API family

citalopram

API family

citalopram

API family

citalopram

API family

citalopram

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

storage temp.

2-30°C

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Citalopram hydrobromide EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Potent and selective serotonin uptake inhibitor (Ki = 5.4 nM); antidepressant

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

comparable product

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Pricing

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1134233

Citalopram hydrobromide, United States Pharmacopeia (USP) Reference Standard

1134244

Citalopram Related Compound A, United States Pharmacopeia (USP) Reference Standard

1134222

Citalopram Related Compound H, United States Pharmacopeia (USP) Reference Standard

1134197

Citalopram Related Compound G, United States Pharmacopeia (USP) Reference Standard

1134288

Citalopram Related Compound E, United States Pharmacopeia (USP) Reference Standard

1134266

Citalopram Related Compound C, United States Pharmacopeia (USP) Reference Standard

1134255

Citalopram Related Compound B, United States Pharmacopeia (USP) Reference Standard

1134277

Citalopram Related Compound D, United States Pharmacopeia (USP) Reference Standard

1134299

Citalopram Related Compound F, United States Pharmacopeia (USP) Reference Standard

Y0001007

Citalopram hydrochloride, European Pharmacopoeia (EP) Reference Standard

1134142

R-Citalopram oxalate, United States Pharmacopeia (USP) Reference Standard

PHR1906

Citalopram Related Compound H, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1863

Citalopram Related Compound F, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1902

Citalopram Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1904

Citalopram Related Compound E, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1903

Citalopram Related Compound D, Pharmaceutical Secondary Standard; Certified Reference Material

BP1153

Citalopram hydrobromide, British Pharmacopoeia (BP) Reference Standard

PHR1905

Citalopram Related Compound G, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1901

Citalopram Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

BP1154

Citalopram impurity standard, British Pharmacopoeia (BP) Reference Standard

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302,H336,H361d,H412

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Gordon F Buchanan et al.
The Journal of physiology, 592(19), 4395-4410 (2014-08-12)
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy. Defects in central control of breathing are important contributors to the pathophysiology of SUDEP, and serotonin (5-HT) system dysfunction may be involved. Here
Yevheniia Mikheenko et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(6), 1395-1404 (2015-01-15)
Trait anxiety is a risk factor for the development and maintenance of affective disorders, and insights into the underlying brain mechanisms are vital for improving treatment and prevention strategies. Translational studies in non-human primates, where targeted neurochemical and genetic manipulations
M D Opal et al.
Molecular psychiatry, 19(10), 1106-1114 (2013-10-30)
Current antidepressants must be administered for several weeks to produce therapeutic effects. We show that selective serotonin 2C (5-HT2C) antagonists exert antidepressant actions with a faster-onset (5 days) than that of current antidepressants (14 days) in mice. Subchronic (5 days)
Jesper T Andreasen et al.
Brain research, 1601, 117-126 (2015-01-13)
Depression and anxiety often co-occur, and conventional monoamine-facilitating antidepressants show efficacy against symptoms in both disorders. Rodent studies indicate that antidepressant effects of monoamine-based antidepressants involve increased α-amino-3-hydroxy-5- methyl-4-isoxazolepropionic acid glutamate receptor (AMPAR) neurotransmission, and positive allosteric modulators (PAMs) at
Laura Jiménez-Sánchez et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(11), 2673-2680 (2014-05-30)
Paradoxically, N-methyl-D-aspartate (NMDA) receptor antagonists are used to model certain aspects of schizophrenia as well as to treat refractory depression. However, the role of different subunits of the NMDA receptor in both conditions is poorly understood. Here we used biochemical
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