This product is tested for suitability in HPLC. The minimum purity of this material is 97%, and the maximum water content is 2.0 mol. These values are lot-specific and reported in the Certificate of Analysis. This material is not tested for use as an analytical standard. Suitability for this application would have to be determined by the end user. Please see the link below to review a sample or lot specific Certificate:
https://www.sigmaaldrich.com/product/sigma/p1499#product-documentation
P1499
Pterostilbene
≥97% (HPLC), apoptosis inducer, solid
Synonym(s):
Pterocarpus marsupium, 3,5-Dimethoxy-4′-hydroxystilbene, 4-[(1E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenol
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10 MG
£266.00
About This Item
Empirical Formula (Hill Notation):
C16H16O3
CAS Number:
Molecular Weight:
256.30
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
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Product Name
Pterostilbene, ≥97% (HPLC), solid
SMILES string
COc1cc(OC)cc(\C=C\c2ccc(O)cc2)c1
InChI key
VLEUZFDZJKSGMX-ONEGZZNKSA-N
InChI
1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+
assay
≥97% (HPLC)
form
solid
storage condition
protect from light
solubility
DMSO: >20 mg/mL
H2O: insoluble
storage temp.
2-8°C
Quality Level
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Related Categories
1 of 4
This Item | 523310 | SML1078 | SML1787 |
|---|---|---|---|
| form solid | form solid | form powder | form powder |
| assay ≥97% (HPLC) | assay ≥95% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| storage condition protect from light | storage condition OK to freeze, protect from light | storage condition protect from light | storage condition - |
| solubility DMSO: >20 mg/mL, H2O: insoluble | solubility DMSO: 10 mg/mL, methanol: 10 mg/mL | solubility DMSO: 20 mg/mL, clear | solubility DMSO: 3 mg/mL, clear (warmed) |
Application
Pterostilbene has been used:
- to investigate its anti-oxidative stress activities and the involvement of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-antioxidant response element (ARE) signaling pathway[1]
- to determine its effects on transcriptional activation of estrogen receptor-α (ERα) in hormone resistant breast cancer cells)[2]
- to study its effects on the cytotoxicity of 2-chloroethyl ethyl sulphide (CEES) in human epidermoid carcinoma cells (A-431) through MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide)viability assay[3]
Biochem/physiol Actions
Antioxidant, antiproliferative, apoptosis inducer, antihyperglycemic, antidiabetic.
Pterostilbene exhibits antineoplastic properties in some of the malignancies, hence it is considered as an active anticancer agent. It has the ability to stimulate apoptosis and block the viability of cell in estrogen-receptor positive and negative breast cancer cell lines.[4]
Disclaimer
Air-sensitive
General description
Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene), an antioxidant is an analogue of resveratrol. It is present in blueberries, tree wood and some types of grapes.[4]
signalword
Danger
hcodes
Hazard Classifications
Aquatic Chronic 2 - Eye Dam. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Shih-Chun Yang et al.
Frontiers in microbiology, 8, 1103-1103 (2017-07-01)
Pterostilbene is a methoxylated derivative of resveratrol originated from natural sources. We investigated the antibacterial activity of pterostilbene against drug-resistant
Hee Jeong Shin et al.
Molecules (Basel, Switzerland), 25(1) (2020-01-16)
Increasing studies have reported that cancer stem cells (CSCs) play critical roles in therapeutic resistance, recurrence, and metastasis of tumors, including cervical cancer. Pterostilbene, a dimethylated derivative of resveratrol, is a plant polyphenol compound with potential chemopreventive activity. However, the
Jaewon Chang et al.
Neurobiology of aging, 33(9), 2062-2071 (2011-10-11)
Recent studies have implicated resveratrol and pterostilbene, a resveratrol derivative, in the protection against age-related diseases including Alzheimer's disease (AD). However, the mechanism for the favorable effects of resveratrol in the brain remains unclear and information about direct cross-comparisons between
Ebselen analogues reduce 2-chloroethyl ethyl sulphide toxicity in A-431 cells
Pino M A, et al.
Arhiv za Higijenu Rada i Toksikologiju, 64(1), 77-86 (2013)
Wasamon Nutakul et al.
Journal of agricultural and food chemistry, 59(20), 10964-10970 (2011-09-23)
The effects of resveratrol and pterostilbene (two structurally related stilbene compounds) on three human colon cancer cells were systematically compared. Cell viability tests indicated that IC(50) values of pterostilbene were 2-5-fold lower than those of resveratrol in all three cancer
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Actually we are using as a Analytical Standard for HPLC assay of Pterostilbene in RM and Final Product .Can we use this? if we can use How much purity we have to take for Calculation
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