SML1921

NVP-ADW742

Name: NVP-ADW742
Brand: SIGMA
Price: 78.03 GBP

≥98% (HPLC)

Synonym(s):

5-[3-(Phenylmethoxy)phenyl]-7-[trans-3-(1-pyrrolidinylmethyl)cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, NVP-ADW 742

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About This Item

Empirical Formula (Hill Notation):

C₂₈H₃₁N₅O

CAS Number:

475488-23-4

Molecular Weight:

453.58

UNSPSC Code:

12352200

NACRES:

NA.77

Key Documents

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Product Name

NVP-ADW742, ≥98% (HPLC)

SMILES string

N6(CCCC6)C[C@@H]1C[C@H](C1)[n]2c3ncnc(c3c(c2)c4cc(ccc4)OCc5ccccc5)N

InChI

1S/C28H31N5O/c29-27-26-25(22-9-6-10-24(15-22)34-18-20-7-2-1-3-8-20)17-33(28(26)31-19-30-27)23-13-21(14-23)16-32-11-4-5-12-32/h1-3,6-10,15,17,19,21,23H,4-5,11-14,16,18H2,(H2,29,30,31)/t21-,23-

InChI key

LSFLAQVDISHMNB-AFARHQOCSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Related Categories

Bioactive Small Molecule Inhibitors

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Show Differences

1 of 4

This Item	SML1973	SML1107	SML0314
Sigma-Aldrich SML1921 NVP-ADW742	Sigma-Aldrich SML1973 NVP-AEW541	Sigma-Aldrich SML1107 SGC0946	Sigma-Aldrich SML0314 CGP77675
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level -	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C
solubility DMSO: 2 mg/mL, clear	solubility DMSO: 2 mg/mL, clear	solubility DMSO: 20 mg/mL, clear	solubility DMSO: >10 mg/mL
color white to beige	color white to beige	color white to beige	color white to beige

Application

NVP-ADW742 has been used as an insulin-like growth factor 1 receptor (IGF1R) inhibitor to test the effects of filamin A (FLNA) silencing in a cell proliferation assay.[1]

Biochem/physiol Actions

Insulin-like growth factor-I (IGF-I) receptor kinase inhibitor

NVP-ADW742 is a potent and selective ATP-competitive inhibitor of Insulin-like growth factor-I receptor (IGF-IR) kinase. NVP-ADW742 sensitizes cancer cell lines to multiple anticancer agents including etoposide, carboplatin, imatinib, vincristine, and doxorubicin.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000473881

0000469123

0000139314

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The cytoskeleton actin binding protein filamin A impairs both IGF2 mitogenic effects and the efficacy of IGF1R inhibitors in adrenocortical cancer cells.

R Catalano et al.

Cancer letters, 497, 77-88 (2020-10-20)

Adrenocortical carcinomas (ACCs) overexpress insulin-like growth factor 2 (IGF2), that drives a proliferative autocrine loop by binding to IGF1R and IR, but IGF1R/IR-targeted therapies failed in ACC patients. The cytoskeleton actin-binding protein filamin A (FLNA) impairs IR signalling in melanoma

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NVP-ADW742