A dual-targeting hybrid platinum(IV) prodrug for enhancing efficacy.

A dual-targeting hybrid platinum(IV) prodrug for enhancing efficacy.

Chemical communications (Cambridge, England) (2012-09-27)

Haihua Xiao, Lesan Yan, Yu Zhang, Ruogu Qi, Wenliang Li, Rui Wang, Shi Liu, Yubin Huang, Yuxin Li, Xiabin Jing

ABSTRACT

A multifunctional hybrid platinum(IV) prodrug, which consists of both the mitochondria-targeting drug DCA and the DNA-crosslinking drug cisplatin, was synthesized and tethered to a carrier polymer to further self-assemble into micelles for intracellular delivery.

MATERIALS

Product Number

Brand

Product Description

36545

Supelco

Dichloroacetic acid, PESTANAL^®, analytical standard

Pricing and availability is not currently available.

707066

Sigma-Aldrich

DCA Deblock (0.36M dichloroacetic acid in toluene)

Pricing and availability is not currently available.

D54702

Sigma-Aldrich

Dichloroacetic acid, ReagentPlus^®, ≥99%

Pricing and availability is not currently available.