Chemical analogues relevant to molybdenum and tungsten enzyme reaction centres toward structural dynamics and reaction diversity.

Recent characterisation of molybdenum and tungsten enzymes revealed novel structural types of reaction centres, as well as providing new subjects of interest as synthetic chemical analogues. This tutorial review highlights the structure/reactivity relationships of the enzyme reaction centres and chemical analogues. Chemical analogues for the oxygen atom transfer enzymes have been well expanded in structure and reactivity. Other types of chemical analogues that exhibit different coordination chemistry have recently been presented for reaction centres of the hydroxylation and dehydrogenation enzymes and others.