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Merck

Role of iron in lung injury-induced by hyperoxia.

Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc (2014-03-22)
D Cao, J Zheng, L F Xian, G M Tang, X J Sun, W G Xu, H Y Tao, K Liu, W W Liu
PMID24649714
ABSTRACT

Iron is essential to life due to its unusual flexibility in serving as both an electron donor and acceptor. However, free iron can damage tissues by catalyzing the conversion of hydrogen peroxide to free-radical ions that attack lipids, proteins and DNA. Hyperoxia-induced lung injury (HILI) occurs when breathing elevated partial pressure of oxygen (usually > 0.5 atmospheres absolute) for extended periods. A few studies have shown that iron and proteins related to iron metabolism are closely related to HILI, and iron chelation may exert protective effects on HILI. As a rate-limiting enzyme in the degradation of heme, heme oxygenases (HOs) play a crucial role in the iron metabolism. Although some studies have been conducted to investigate the role of HOs in the pathogenesis of HILI, findings still conflict, and HOs of different isoforms may function differently in the pathogenesis of HILI. On the available findings, there might be a beneficial threshold of HO-1 expression in HILI. More studies are required to confirm the above findings and to provide evidence for the clinical treatment of HILI by iron chelation.

MATERIALS
Product Number
Brand
Product Description
338141
Sigma-Aldrich
Iron, foil, thickness 0.25 mm, ≥99.99% trace metals basis
12310
Sigma-Aldrich
Iron, ≥99%, reduced, powder (fine)
C3518
Sigma-Aldrich
Carbonyl iron, ≥97% Fe basis
413054
Sigma-Aldrich
Iron, granular, 10-40 mesh, >99.99% trace metals basis
GF80015587
Iron, foil, 1m coil, thickness 0.038mm, hard, 99.5%
GF80813831
Iron, foil, 15mm disks, thickness 0.25mm, as rolled, 99.99+%
GF63582970
Iron, tube, 1000mm, outside diameter 2.0mm, inside diameter 1.08mm, wall thickness 0.46mm, as drawn, 99.5%
GF07290176
Iron, tube, 100mm, outside diameter 15.0mm, inside diameter 12mm, wall thickness 1.5mm, annealed, 99.5%
GF80952554
Iron, tube, 100mm, outside diameter 4.0mm, inside diameter 3.6mm, wall thickness 0.2mm, as drawn, 99.5%
GF52587715
Iron, tube, 500mm, outside diameter 4.0mm, inside diameter 3.6mm, wall thickness 0.2mm, as drawn, 99.5%
GF64909660
Iron, tube, 500mm, outside diameter 20.0mm, inside diameter 16mm, wall thickness 2.0mm, annealed, 99.5%
GF61886571
Iron, tube, 500mm, outside diameter 3.2mm, inside diameter 2.2mm, wall thickness 0.5mm, as drawn, 99.8%
GF13964575
Iron, foil, 50x50mm, thickness 0.25mm, hard, 99.5%
GF13708122
Iron, tube, 1000mm, outside diameter 20.0mm, inside diameter 16mm, wall thickness 2.0mm, annealed, 99.5%
GF34818824
Iron, tube, 100mm, outside diameter 5.0mm, inside diameter 4.5mm, wall thickness 0.25mm, as drawn, 99.5%
GF81466432
Iron, tube, 500mm, outside diameter 25.0mm, inside diameter 21mm, wall thickness 2mm, annealed, 99.5%
GF29377154
Iron, tube, 100mm, outside diameter 2.0mm, inside diameter 1.08mm, wall thickness 0.46mm, as drawn, 99.5%
GF11271462
Iron, tube, 200mm, outside diameter 15.0mm, inside diameter 12mm, wall thickness 1.5mm, annealed, 99.5%
GF70344097
Iron, tube, 200mm, outside diameter 3.2mm, inside diameter 2.2mm, wall thickness 0.5mm, as drawn, 99.8%
GF78531666
Iron, tube, 100mm, outside diameter 2.30mm, inside diameter 2.07mm, wall thickness 0.115mm, as drawn, 99.5%
GF72144862
Iron, tube, 200mm, outside diameter 2.0mm, inside diameter 1.08mm, wall thickness 0.46mm, as drawn, 99.5%
GF48249210
Iron, tube, 100mm, outside diameter 2.0mm, inside diameter 1.6mm, wall thickness 0.2mm, as drawn, 99.5%
GF48694179
Iron, foil, 300x300mm, thickness 0.38mm, hard, 99.5%
GF75909336
Iron, foil, 10m coil, thickness 0.125mm, hard, 99.5%
GF38053953
Iron, foil, 300x300mm, thickness 3.0mm, as rolled, 99.5%
GF66530594
Iron, foil, light tested, 25x25mm, thickness 0.01mm, 99.85%
GF77739272
Iron, foil, 5m coil, thickness 0.25mm, hard, 99.5%
GF75874742
Iron, foil, light tested, 25x25mm, thickness 0.025mm, as rolled, 99.99+%
GF65510861
Iron, insulated wire, 20m, conductor diameter 0.25mm, insulation thickness 0.01mm, polyester insulation
GF78366156
Iron, foil, not light tested, 100x100mm, thickness 0.015mm, 99.85%