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14-629-M

JAK3 Protein, active, 10 µg

Active, N-terminal His6-tagged, recombinant, human JAK3 amino acids 781-end, for use in Kinase Assays.

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14-629

€569.00

€569.00

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About This Item

UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.32

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biological source

human

Quality Level

100

recombinant

expressed in baculovirus infected Sf21 cells

product line

Upstate®

specific activity

(For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)

mol wt

Mw 39.9 kDa

purified by

(Ni2+/NTA-agarose)

species reactivity

human

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

accession no.

 (FUNCTION: SwissProt: P52333 # Tyrosine kinase of the non-receptor type, involved in the interleukin-2 and interleukin-4 signaling pathway. Phosphorylates STAT6, IRS1, IRS2 and PI3K. )
NM_000215.2

NCBI accession no.

NM_000215.2

UniProt accession no.

P52333

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This Item
14-640-M14-501-M14-683-M
JAK3 Protein, active, 10 µg Active, N-terminal His6-tagged, recombinant, human JAK3 amino acids 781-end, for use in Kinase Assays.

Sigma-Aldrich

14-629-M

JAK3 Protein, active, 10 µg

JAK2 Protein, active, 10 µg Active, C-terminal His6-tagged, recombinant, human JAK2, amino acids 808-end, expressed by baculovirus in Sf21 cells, for use in Enzyme Assays.

Sigma-Aldrich

14-640-M

JAK2 Protein, active, 10 µg

JNK3/SAPK1b Protein, active, 10 µg Active, N-terminal His6 tagged, recombinant, full length human JNK3/SAPK1b, for use in Kinase Assays.

Sigma-Aldrich

14-501-M

JNK3/SAPK1b Protein, active, 10 µg

PAK3 Protein, active, 10 µg Active, C-terminal 6His-tagged, recombinant, human full length, PAK3. For use in Kinase Assays.

Sigma-Aldrich

14-683-M

PAK3 Protein, active, 10 µg

biological source

human

biological source

human

biological source

human

biological source

human

recombinant

expressed in baculovirus infected Sf21 cells

recombinant

expressed in baculovirus infected Sf21 cells

recombinant

expressed in Sf21 cells

recombinant

expressed in baculovirus infected Sf21 cells

technique(s)

activity assay: suitable (kinase)

technique(s)

activity assay: suitable

technique(s)

activity assay: suitable (kinase)

technique(s)

activity assay: suitable (kinase)

mol wt

Mw 39.9 kDa

mol wt

Mw 38.9 kDa

mol wt

Mw 53 kDa

mol wt

Mw 63.2 kDa

UniProt accession no.

P52333

UniProt accession no.

O60674

UniProt accession no.

P53779

UniProt accession no.

O75914

specific activity

(For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)

specific activity

-

specific activity

-

specific activity

-

General description

JAK3
N-terminal His6-tagged, recombinant, human JAK3 amino acids 781-end

Application

Research Category
Inflammation & Immunology

Biochem/physiol Actions

Protein Target: JAK3
Target Sub-Family: TK

Packaging

Also available in 10 μg size and in bulk
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-629M when ordering the 250 µg size.

Physical form

Ni2+/NTA-agarose

Preparation Note

6 months at -70°C

Analysis Note

routinely evaluated by phosphorylation of 500μM JAK3tide (Catalog # 12-547)

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317

Hazard Classifications

Skin Sens. 1

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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B A Witthuhn et al.
Nature, 370(6485), 153-157 (1994-07-14)
Many cytokines function through interaction with receptors of the cytokine receptor superfamily. Although lacking catalytic domains, cytokine receptors couple ligand binding to induction of protein tyrosine phosphorylation. Recent studies have shown that one or more of the Janus kinase family
J A Johnston et al.
Nature, 370(6485), 151-153 (1994-07-14)
Interleukin-2 is an autocrine growth factor for T cells which also activates other cells including B cells and natural killer cells. The subunits of the interleukin-2 receptor (IL-2R) lack intrinsic enzymatic activity, but protein tyrosine phosphorylation is a critical event

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