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Merck

30078

Cysteamine hydrochloride

BioXtra

Synonym(s):

β-Mercapto­ethylamine hydrochloride, 2-Amino­ethane­thiol hydrochloride, 2-Mercapto­ethyl­amine hydrochloride, Decarboxy­cysteine hydrochloride, Thio­ethanol­amine hydrochloride

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€134.00

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€426.00

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About This Item

Linear Formula:
HSCH2CH2NH2 · HCl
CAS Number:
156-57-0
Molecular Weight:
113.61
UNSPSC Code:
41106305
NACRES:
NA.51
PubChem Substance ID:
329753424
EC Number:
205-858-1
Beilstein/REAXYS Number:
3590083
MDL number:
MFCD00012904

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Product Name

Cysteamine hydrochloride, BioXtra

InChI

1S/C2H7NS.ClH/c3-1-2-4;/h4H,1-3H2;1H

InChI key

OGMADIBCHLQMIP-UHFFFAOYSA-N

SMILES string

Cl[H].NCCS

product line

BioXtra

Quality Level

200

assay

98.0-101.0% (redox titration)

form

crystals
powder

mol wt

113.61 g/mol

concentration

≤100% (2-aminoethanethiol hydrochloride)

color

colorless to white

pH

3.5-5.0 (25 °C, 1 M in H2O)

mp

67-71 °C

solubility

H2O: 1 m at 20 °C, clear, colorless

anion traces

sulfate (SO42-): ≤50 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.5 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤50 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

absorption

cut-off at 270 nm in H2O at 1 M

λ

1 M in H2O

UV absorption

λ: 280 nm Amax: ≤0.3

storage temp.

2-8°C

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Show Differences

1 of 4

This Item
137139PHR9273M6500
Cysteamine hydrochloride BioXtra

Sigma-Aldrich

30078

Cysteamine hydrochloride

Cysteamine hydrochloride EMPROVE® ESSENTIAL

SAFC

137139

Cysteamine hydrochloride

Cysteamine hydrochloride certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Supelco

PHR9273

Cysteamine hydrochloride

Cysteamine hydrochloride ≥98% (titration)

Sigma-Aldrich

M6500

Cysteamine hydrochloride

solubility

H2O: 1 m at 20 °C, clear, colorless

solubility

-

solubility

-

solubility

water: 50 mg/mL, clear, colorless to very faintly yellow

Quality Level

200

Quality Level

500

Quality Level

300

Quality Level

300

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

mp

67-71 °C

mp

67-71 °C

mp

67-71 °C

mp

67-71 °C

product line

BioXtra

product line

EMPROVE® ESSENTIAL

product line

TraceCERT®

product line

-

pH

3.5-5.0 (25 °C, 1 M in H2O)

pH

-

pH

-

pH

-

Application

Cysteamine is used in a wide range of applications such as regulation of gene expression, depletion of somatostatin and coating of nanoparticles. It may be used to study the potential value of cystine in metabolism disorders such as cystinosis. Cysteamine may be used as a redox sensitive component in biosensor development.

General description

Cysteamine is an aminothiol that can reduce important oxidized disulfide molecules such as cystine to yield cysteine.

Other Notes

Aminothiol radioprotector;[1] Inducer of duodenal ulcers in rodents;[2] Depletes somatostatin concentration in rat tissues.[3][4]

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN4583
BCCM9556
BCCM9866
BCCM6639
BCCL1773

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R Widmann et al.
Journal of neurochemistry, 50(6), 1682-1686 (1988-06-01)
Cysteamine and its dimeric form cystamine have been applied to the rat striatum by local injection. Both compounds resulted in a dose-dependent decrease of somatostatin levels. Maximal reduction of somatostatin (by about 50%) was obtained at a dose of 50
D. Vasilescu et al.
International Journal of Quantum Chemistry, 14, 149-149 (1987)
Mengxiao Yu et al.
Journal of the American Chemical Society, 133(29), 11014-11017 (2011-07-01)
pH regulates many cellular processes and is also an indicator of disease progression. Therefore, pH-responsive materials often serve as either tools in the fundamental understanding of cell biology or medicine for disease diagnosis and therapy. While gold nanoparticles have broad
S Szabo et al.
Endocrinology, 109(6), 2255-2257 (1981-12-01)
Administration of cysteamine (mercaptoethylamine) induces in rats severe perforating duodenal ulcers. Because the ulcerogenic properties of cysteamine are markedly reduced by treatment with somatostatin, we considered the possibility that cysteamine-induced duodenal ulcer might be mediated by depletion of tissue somatostatin
Jamin B Hein et al.
Bio-protocol, 10(13), e3669-e3669 (2021-03-05)
Every living cell relies on signal transduction pathways comprised of protein-protein interactions (PPIs). In many cases, these PPIs are between a folded protein domain and a short linear motif (SLiM) within an unstructured region of a protein. As a result
View All Related Papers

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