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About This Item
Conjugate:
unconjugated
Clone:
O4, monoclonal
Application:
FACS, ICC
Citations:
37
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
O4, monoclonal
form
lyophilized powder
species reactivity
mouse, rat, chicken, human
technique(s)
flow cytometry: 0.25 μg/106 cells (rate differentiated cortical stem cells), immunocytochemistry: 1-10 μg/mL
isotype
IgM
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... OMG(4974)
General description
Monoclonal anti-oligodendrocyte marker O4 was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with white matter of the corpus callosum from bovine brain. Oligodendrocytes are myelinating cells in the central nervous system (CNS) that form the myelin sheath of axons to support rapid nerve conduction.
Immunogen
white matter of corpus callosum from bovine brain.
Application
Monoclonal anti-oligodendrocyte marker O4 antibody produced in mouse has been used in immunocytochemistry and immunofluorescence.
Biochem/physiol Actions
Oligodendrocyte marker O4 functions as a development marker of oligodendrocytes. The monoclonal anti-oligodendrocyte marker O4 antibody has been used to describe a biologically distinct stage of the oligodendroglial lineage in-vitro.†
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Xiao-Long Guo et al.
Communications biology, 2, 59-59 (2019-02-19)
Bacterial pore-forming toxin aerolysin-like proteins (ALPs) are widely distributed in animals and plants. However, functional studies on these ALPs remain in their infancy. βγ-CAT is the first example of a secreted pore-forming protein that functions to modulate the endolysosome pathway
Shuhui Yang et al.
ACS omega, 4(19), 18136-18146 (2019-11-14)
Neural stem cells (NSCs) play an important role in neural tissue engineering because of their capacity of self-renewal and differentiation to multiple cell lineages. The in vitro conventional neurosphere culture protocol has some limitations such as limited nutrition and oxygen
An efficient and economical culture approach for the enrichment of purified oligodendrocyte progenitor cells.
Niu J, et al.
Journal of Neuroscience Methods, 209, 241-249 (2012)
SDF-1a Secreted by Human CD133-Derived Multipotent Stromal Cells Promotes Neural Progenitor Cell Survival Through CXCR7
Benjamin Bakondi
Stem Cells and Development (2011)
M2 microglia promotes neurogenesis and oligodendrogenesis from neural stem/progenitor cells via the PPAR? signaling pathway
Jichao Yuan
Oncotarget (2017)
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