Skip to Content
Merck

AB5849

Anti-Glutamate Receptor 1 Antibody, phosphoSer 845

Chemicon®, from rabbit

Synonym(s):

GluR1

Slide 1 of 1
Sign In to View Organizational & Contract Pricing

Select a Size

25 μL

₩218,834

150 μL

₩734,048

₩218,834

Estimated to ship onJanuary 26, 2026Details

Request a Bulk Order

About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Key Documents

View All Documentation

Skip To

Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

biological source

rabbit

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat

packaging

antibody small pack of 25 μL

manufacturer/tradename

Chemicon®

technique(s)

western blot: suitable

NCBI accession no.

NM_000827.2

UniProt accession no.

P42261

shipped in

dry ice

target post-translational modification

phosphorylation (pSer845)

Gene Information

human ... GRIA1(2890)

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
AB5847SAB5700489AB1504
Anti-Glutamate Receptor 1 Antibody, phosphoSer 845 Chemicon®, from rabbit

Sigma-Aldrich

AB5849

Anti-Glutamate Receptor 1 Antibody, phosphoSer 845

Anti-Glutamate Receptor 1 Antibody, phosphoSer 831 Chemicon®, from rabbit

Sigma-Aldrich

AB5847

Anti-Glutamate Receptor 1 Antibody, phosphoSer 831

Anti-Phospho-GRIA1-S845 antibody produced in rabbit

Sigma-Aldrich

SAB5700489

Anti-Phospho-GRIA1-S845 antibody produced in rabbit

Anti-Glutamate receptor 1 Antibody from rabbit, purified by affinity chromatography

Sigma-Aldrich

AB1504

Anti-Glutamate receptor 1 Antibody

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

antibody form

affinity purified immunoglobulin

antibody form

affinity purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

species reactivity

rat

species reactivity

rat

species reactivity

mouse, human, rat

species reactivity

rat, horse, mouse, human

Gene Information

human ... GRIA1(2890)

Gene Information

human ... GRIA1(2890)

Gene Information

human ... GRIA1(2890)

Gene Information

human ... GRIA1(2890)

technique(s)

western blot: suitable

technique(s)

western blot: suitable

technique(s)

western blot: 1:500-1:2000

technique(s)

immunohistochemistry: suitable (paraffin), immunoprecipitation (IP): suitable, western blot: suitable

General description

100 kDa
Glutamate receptor 1 (AMPA) belongs to the glutamate-gated ion channel and binds AMPA, glutamate and kainate. L-Glutamate is the major excitatory neurotransmitter in the mammalian CNS, acting through both ligand gated ion channels (ionotropic receptors; composed of subunits GluR1-4) and G-protein coupled (metabotropic) receptors. The AMPA glutamate receptors mediate fast synaptic transmission in the CNS.

Immunogen

Epitope: phosphoSer 845
Synthetic peptide corresponding to amino acids surrounding the phosphoSer845 of rat GluR1.

Application

Anti-Glutamate Receptor 1 Antibody, phosphoSer 845 is an antibody against Glutamate Receptor 1 for use in WB.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Western blot: 1:1,000

Optimal working dilutions must be determined by the end user.

Biochem/physiol Actions

Recognizes Glutamate Receptor 1 [GluR1], phosphoSe845. The antibody recognizes a protein of 100 kDa corresponding to GluR1 phosphorylated at Ser845.

Physical form

Affinity Purified immunoglobulin. Liquid in 10 mM HEPES, pH 7.5, with 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.
ImmunoAffinity Purified

Preparation Note

Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Analysis Note

Control
Human brain tissue

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Shan Liu et al.
Brain research, 1400, 31-41 (2011-06-07)
Previously, a learning-free measure was used to demonstrate that chronic food restriction (FR) increases the reward magnitude of a wide range of abused drugs. Moreover, a variety of striatal neuroadaptations were detected in FR subjects, some of which are known
Learning-induced glutamate receptor phosphorylation resembles that induced by long term potentiation.
Shukla, K; Kim, J; Blundell, J; Powell, CM
The Journal of Biological Chemistry null
C A Woods et al.
Physiology & behavior, 159, 52-63 (2016-03-19)
With respect to feeding, insulin is typically thought of as a satiety hormone, acting in the hypothalamus to limit ingestive behavior. However, accumulating evidence suggests that insulin also has the ability to alter dopamine release in the striatum and influence
Caroline Jung et al.
Psychopharmacology, 233(17), 3161-3172 (2016-07-05)
When ad libitum-fed rats undergo cocaine place preference conditioning (CPP) but are switched to food restriction for testing, CPP becomes resistant to extinction and correlates with phosphorylation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluA1 at Ser845 in nucleus accumbens (NAc) core.
Dipen Rajgor et al.
The Journal of biological chemistry, 292(23), 9774-9786 (2017-04-14)
MicroRNAs (miRNAs) are important regulators of localized mRNA translation in neuronal dendrites. The presence of RNA-induced silencing complex proteins in these compartments and the dynamic miRNA expression changes that occur in response to neuronal stimulation highlight their importance in synaptic
View All Related Papers

Related Content

RABBIT ANTI-GLUTAMATE RECEPTOR 1 phosphoSer845 AFFINITY PURIFIED POLYCLONAL ANTIBODY
Pathways and Biomarkers of Glutamatergic Synapse Flyer

Glutamate is an excitatory neurotransmitter found in the synaptic vesicles of glutamatergic synapses. The post-synaptic neurons in these synapses contain ionotropic and metabotropic glutamate receptors. Glutamate binds to AMPA (α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid) subtype glutamate receptors, leading to sodium influx into the post-synaptic cell and resulting in neuronal excitability and synaptic transmission. The NMDA (N-methyl-d-aspartate) subtype glutamate receptors, on the other hand, regulate synaptic plasticity, and can influence learning and memory. The metabotropic g-protein coupled mGluRs modulate downstream calcium signaling pathways and indirectly influence the synapse’s excitability. The synaptic architecture includes intracellular scaffolding proteins (PSD-95, GRIP), intercellular cell adhesion molecules (NCAMs, N-Cadherins), and a variety of signaling proteins (CaMKII/PKA, PP1/PP2B). Processes critical for synaptic transmission and plasticity are influenced by these molecules and their interactions. When the function of these molecules is disrupted, it leads to synaptic dysfunction and degeneration, and can contribute to dementia as seen in Alzheimer’s disease.

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service