Pramipexole dihydrochloride (A1237) is described with the synonym (S)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride, indicating it is the S (L) enantiomer. The optical rotation is measured and can be found in the Certificate of Analysis (COA) for this product. The specification for this product is between -60° and -70°, which is consistent with the S (L) enantiomer of pramipexole.
A1237
Pramipexole dihydrochloride
>98% (HPLC), Dopamine D2 and D3 receptor agonist, powder
동의어(들):
(S)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride, PPX dihydrochloride
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
보기 변경
| 사이즈/SKU | 재고 정보 | 가격 (VAT 별도) |
|---|---|---|
10 mg | 구입 가능 여부는 고객센터에 문의하십시오. | ₩163,923 |
50 mg | 오늘 배송 가능재고 수량 조회Seoul Warehouse South Korea | ₩696,696 |
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C10H17N3S · 2HCl
CAS 번호:
Molecular Weight:
284.25
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
eCl@ss:
32150313
Assay:
>98% (HPLC)
Form:
powder
Storage condition:
desiccated
제품 이름
Pramipexole dihydrochloride, >98% (HPLC), powder
Quality Segment
assay
>98% (HPLC)
form
powder
storage condition
desiccated
color
white to off-white
solubility
H2O: >20 mg/mL
originator
Boehringer Ingelheim
storage temp.
2-8°C
SMILES string
Cl.Cl.CCCN[C@H]1CCc2nc(N)sc2C1
InChI
1S/C10H17N3S.2ClH/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;/h7,12H,2-6H2,1H3,(H2,11,13);2*1H/t7-;;/m0../s1
InChI key
QMNWXHSYPXQFSK-KLXURFKVSA-N
Gene Information
human ... DRD2(1813), DRD3(1814), DRD4(1815)
General description
Pramipexole belongs to non-ergoline class and is derived from benzothiazole. It has strong affinity for D2 and D3 receptors (dopamine receptors) compared to other ergoline-derived drugs. However, it does not associate with non-dopamine receptors, for instance adrenergic and serotonin receptors.
Application
Biochem/physiol Actions
Pramipexole elicits neuroprotective role and may help in treating depression. It also has a potential to modulate limb movement and may be effective in treating restless legs syndrome.
Pramipexole is a therapeutic agent for Parkinson′s disease and restless leg syndrome. It also exhibits antidepressant responses in patients suffering from MDD (major depressive disorder) and bipolar depression.
Pramipexole dihydrochloride monohydrate is a dopamine agonist active at D3 and D2 receptor subtypes.
Pramipexole is a dopamine agonist active at D3 and D2 receptor subtypes. Pramipexole has been found to have neuroprotective effects independent of its dopamine receptor agonism. It reduces mitochondrial reactive oxygen species (ROS) production and inhibits the activation of apoptotic pathways.
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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이 품목 | |
|---|---|
| description >98% (HPLC), powder | description Pharmaceutical Secondary Standard; Certified Reference Material |
| assay >98% (HPLC) | assay - |
| form powder | form - |
| Quality Level 100 | Quality Level 300 |
| storage temp. 2-8°C | storage temp. 2-30°C |
| solubility H2O: >20 mg/mL | solubility - |
| storage condition desiccated | storage condition - |
경고어
Warning
위험 코드
Hazard Classifications
Acute Tox. 4 Oral - STOT SE 3
표적 장기
Central nervous system
저장 등급
11 - Combustible Solids
WGK
WGK 2
인화점 (F)
Not applicable
인화점 (°C)
Not applicable