SML2139
MDL-860
≥98% (HPLC)
동의어(들):
2-(3,4-Dichlorophenoxy)-5-nitrobenzonitrile
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크기 선택
보기 변경
| 사이즈/SKU | 재고 정보 | 가격 (VAT 별도) |
|---|---|---|
25 mg | 구입 가능 여부는 고객센터에 문의하십시오. | ₩484,967 |
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C13H6Cl2N2O3
CAS 번호:
Molecular Weight:
309.10
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
₩484,967
구입 가능 여부는 고객센터에 문의하십시오.
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
ClC1=CC=C(OC2=CC=C([N+]([O-])=O)C=C2C#N)C=C1Cl
InChI
1S/C13H6Cl2N2O3/c14-11-3-2-10(6-12(11)15)20-13-4-1-9(17(18)19)5-8(13)7-16/h1-6H
InChI key
QAYKDRUKUZJJSO-UHFFFAOYSA-N
Biochem/physiol Actions
MDL-860 is a 5-nitro-2-phenoxybenzonitrile that exerts broad-spectrum antipicornaviral activity (MIC50 from 0.1-1.5 μg/mL in HeLa cultures) by acting as an irreversible inhibitor against host phosphatidylinositol-4 kinase beta (PI4KB; PtdIns 4-kinase beta; PI4Kbeta; NPIK; PI4K92) via covalent modification of Cys646 located at the bottom of a surface pocket apart from the PI4KB active site. MCL-860 (MIC50 from 0.1-1.5 μg/mL in HeLa cultures). A pleconaril/MDL-860/oxoglaucine consecutive alternating administration (CAA), but not simultaneous daily treatment, is reported to be effective against coxsackievirus B1 infection without the development of drug resistance in newborn mice (75 mg/kg MDL-860 via s.c. every third day on the day following pleconaril and prior to oxoglaucine).
Phosphatidylinositol 4-kinase Beta (PI4KB) inhibitor with broad-spectrum antipicornavirus activity.
1 of 1
이 품목 | ||
|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description targeting mouse Pi4kb |
| form powder | form powder | form lyophilized powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C |
| solubility DMSO: 2 mg/mL, clear | solubility DMSO: 2 mg/mL, clear | solubility - |
| color white to beige | color white to beige | color - |
MDL-860 phosphatidylinositol-4 kinase beta inhibitor | - | - |
경고어
Warning
위험 코드
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Oral
저장 등급
11 - Combustible Solids
무슨 일이 일어나고 있는 걸까?
WGK 3
인화점 (F)
Not applicable
인화점 (°C)
Not applicable