1.37096

D-Mannitol

EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP, USP

• Synonym(s): Mannite
• Empirical Formula (Hill Notation): C₆H₁₄O₆
• CAS Number: 69-65-8
• Molecular Weight: 182.17
• EC Index Number: 200-711-8
• UNSPSC Code: 12352201
• Beilstein/REAXYS Number: 1721898
• MDL number: MFCD00064287

Properties

• Product Name: D-Mannitol, EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP, USP
• SMILES string: OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
• InChI key: FBPFZTCFMRRESA-KVTDHHQDSA-N
• InChI: 1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1
• agency: BP; ChP; JP; Ph. Eur.; USP
• product line: EMPROVE^® EXPERT
• form: solid
• autoignition temp.: 410 °C
• pH: 5-7 (20 °C, 100 g/L in H₂O)
• bp: 290-295 °C/4 hPa
• mp: 167-170 °C (lit.)
• solubility: 213 g/L
• application(s): liquid formulation; ophthalmics; parenterals; pharma/biopharma processes; pharmaceutical; semi-solid formulation; solid formulation
• storage temp.: 2-25°C
• Quality Level: 500

Description

Application

Mannitol is a sugar alcohol which is used widely in biomolecule formulations as a stabilizer, bulking agent, and lyoprotecting agent, especially in lyophilization.
Due to its low microbial and endotoxin limits, D(-)-Mannitol Emprove^® Expert is especially suitable for high-risk applications.

Biochem/physiol Actions

A sugar alcohol sweet tastant. Used in sweetness inhibition studies.

General description

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable