Microcon and Amicon Ultra products are very similar. Both concentrate liquids down to a retentate and a filtrate. Substances bigger than the molecular weight cutoff stay on top of the membrane and are reduced from a larger initial volume to a smaller final volume. Two key differences are: the Microcon can be slightly better to use for substances in lower initial concentrations and when substances are sticky. Higher recovery can occur with Microcon due to the product being physically smaller and thus, less product is lost to the hold up volume of the membrane and plastic sides of the tube.
MRCPRT010
Microcon® Centrifugal Filters
NMWCO 10 kDa, Ultracel® regenerated cellulose membrane (low binding), sample volume 0.5 mL
Synonym(s):
Centrifuge concentrator
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About This Item
UNSPSC Code:
41104916
eCl@ss:
36100101
NACRES:
NB.24
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material
Ultracel® regenerated cellulose membrane (low binding)
polyacetal base (membrane support)
polycarbonate device top
polypropylene tube (for filtrate/concentrate)
silicone O-ring (medical-grade)
Quality Level
sterility
non-sterile
feature
holdup volume> 10 μL
packaging
pkg of 100 ea
manufacturer/tradename
Microcon®
parameter
0.5 mL sample volume
technique(s)
DNA purification: suitable
RNA purification: suitable
protein extraction: suitable
protein purification: suitable
L
4.50 cm (1.8 in.)
diam.
12.3 mm
filtration area
0.32 cm2
working volume
0.5 mL
pore size
10 kDa NMWCO
shipped in
ambient
1 of 4
This Item | MRCF0R030 | MRCF0R100 | MRCF0R100ET |
|---|---|---|---|
| pore size 10 kDa NMWCO | pore size 30 kDa NMWCO | pore size - | pore size - |
| manufacturer/tradename Microcon® | manufacturer/tradename Microcon® | manufacturer/tradename Microcon® | manufacturer/tradename Microcon® |
| material Ultracel® regenerated cellulose membrane (low binding), polycarbonate device top, silicone O-ring (medical-grade), polyacetal base (membrane support), polypropylene tube (for filtrate/concentrate) | material Ultracel® regenerated cellulose membrane (low binding), polyacetal base (membrane support), polycarbonate device top, polypropylene tube (for filtrate/concentrate), silicone O-ring (medical-grade) | material Ultracel® regenerated cellulose membrane (low binding), polyacetal base (membrane support), polycarbonate device top, polypropylene tube (for filtrate/concentrate), silicone O-ring (medical-grade) | material Ultracel® regenerated cellulose membrane (low binding), polyacetal base (membrane support), polycarbonate device top, polypropylene tube (for filtrate/concentrate), silicone O-ring (medical-grade, dual cycle ethylene oxide (EtO) treated) |
| sterility non-sterile | sterility non-sterile | sterility non-sterile | sterility non-sterile |
| parameter 0.5 mL sample volume | parameter 0.5 mL sample volume | parameter 0.5 mL sample volume | parameter 0.5 mL sample volume |
| feature holdup volume> 10 μL | feature holdup volume> 10 μL | feature holdup volume> 10 μL | feature holdup volume> 10 μL |
General description
Filter Code: PL, Ultracel® low binding regenerated cellulose
Filter Type: Ultrafiltration
Simply and efficiently concentrate and desalt solutions of any macromolecule, using any centrifuge that can accept 1.5 mL tubes. With the low-binding Ultracel membrane, Microcon filters offer:
•Typical recoveries of greater than 95%, even for dilute solutions
•Reverse spin to maximize recovery, even in the smallest samples
•Convenient storage of filtrate or concentrated sample in standard microfuge tube
•Concentration factors up to 100X
Features:
•High recovery for small volumes with reverse spin (concentration factor less than 20X)
•Low-binding Ultracel membrane
•Fast processing
•Typical recoveries of greater than 95%, even for dilute solutions
•Reverse spin to maximize recovery, even in the smallest samples
•Convenient storage of filtrate or concentrated sample in standard microfuge tube
•Concentration factors up to 100X
Features:
•High recovery for small volumes with reverse spin (concentration factor less than 20X)
•Low-binding Ultracel membrane
•Fast processing
Application
This 0.5 mL centrifugal filter enables the concentration of biomolecules with a membrane NMWL of 10 kDa. Micron centrifugal filters are ideal for DNA & protein concentration & desalting.
Features and Benefits
Minimum Final Concentrate Volume: 50 µL
Physical form
Color Code: Green
Other Notes
Replaces: 42407
Legal Information
MICROCON is a registered trademark of Merck KGaA, Darmstadt, Germany
ULTRACEL is a registered trademark of Merck KGaA, Darmstadt, Germany
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Lilly Toker et al.
Chemico-biological interactions, 319, 109007-109007 (2020-02-23)
Acetylcholinesterase (AChE) terminates cholinergic neurotransmission by hydrolyzing acetylcholine. The collagen-tailed AChE tetramer is a product of 2 genes, ACHE and ColQ. The AChE tetramer consists of 4 identical AChE subunits and one polyproline-rich peptide, whose function is to hold the
Ruth Fair-Mäkelä et al.
Mucosal immunology, 13(2), 245-256 (2019-11-28)
All leukocytes can get entrance into the draining lymph nodes via the afferent lymphatics but only lymphoid cells can leave the nodes. The molecular mechanisms behind this phenomenon have remained unknown. We employed genome wide microarray analyses of the subcapsular
Yaowei Liu et al.
Food chemistry, 314, 126177-126177 (2020-01-20)
This study mainly investigated changes in milk serum proteins by simulating the industrial processing of whole milk powder using a label-free proteomic approach. A total of 391 proteins were identified, 89 of which were quantified in all groups. Compared with
Gulzhan Trimova et al.
Arthritis research & therapy, 22(1), 24-24 (2020-02-14)
14-3-3η is an intracellular protein also detected in the serum and synovial fluid of patients with rheumatoid arthritis (RA). It is closely related to disease activity and anti-cyclic citrullinated peptide antibody levels. However, the main source of 14-3-3η and the
Anthony O Beas et al.
Nature communications, 11(1), 2790-2790 (2020-06-05)
Age-dependent changes in metabolism can manifest as cellular lipid accumulation, but how this accumulation is regulated or impacts longevity is poorly understood. We find that Saccharomyces cerevisiae accumulate lipid droplets (LDs) during aging. We also find that over-expressing BNA2, the
Related Content
The new dual cycle EtO-treated Microcon® DNA Fast Flow PCR Grade devices enable centrifugal concentration at a similar rate as the Microcon® DNA Fast Flow devices, but the EtO treatment greatly reduces the risk that no uncontrolled contaminating nucleic acids enter the analysis process. Both Microcon® devices exhibit faster flow rate (volume filtered per minute) compared to competitor centrifugal products.
Microcon® Centrifugal Filters simply and efficiently concentrate and desalt solutions of any macromolecule, using any centrifuge that can accept 1.5 mL tubes. The low nonspecific binding characteristics of the Ultracel® membrane and the other device components, coupled with its medical-grade o-ring seal, allows the device to accommodate several wash steps with minimal sample loss.
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