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I0599990

Isoprenaline hydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Isoprenaline hydrochloride, (±)-Isoproterenol hydrochloride, 1-(3′,4′-Dihydroxyphenyl)-2-isopropylaminoethanol hydrochloride, N-Isopropyl-DL-noradrenaline hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C11H17NO3 · HCl
CAS Number:
51-30-9
Molecular Weight:
247.72
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329815319
MDL number:
MFCD00012603
Beilstein/REAXYS Number:
3917363

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Product Name

Isoprenaline hydrochloride, European Pharmacopoeia (EP) Reference Standard

SMILES string

Cl.CC(C)NCC(O)c1ccc(O)c(O)c1

InChI key

IROWCYIEJAOFOW-UHFFFAOYSA-N

InChI

1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H

grade

pharmaceutical primary standard

API family

isoprenaline

manufacturer/tradename

EDQM

mp

165-175 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Gene Information

human ... ADRB1(153), ADRB2(154), ADRB3(155)

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1 of 4

This Item
BP205I56271351005
Isoprenaline hydrochloride European Pharmacopoeia (EP) Reference Standard

I0599990

Isoprenaline hydrochloride

Isoprenaline hydrochloride British Pharmacopoeia (BP) Reference Standard

BP205

Isoprenaline hydrochloride

Isoprenaline hydrochloride

Sigma-Aldrich

I5627

Isoprenaline hydrochloride

Isoproterenol hydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1351005

Isoproterenol hydrochloride

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

-

grade

pharmaceutical primary standard

manufacturer/tradename

EDQM

manufacturer/tradename

BP

manufacturer/tradename

-

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical
pharmaceutical small molecule

application(s)

-

application(s)

pharmaceutical (small molecule)

format

neat

format

neat

format

-

format

neat

API family

isoprenaline

API family

isoprenaline

API family

-

API family

isoproterenol

mp

165-175 °C (dec.) (lit.)

mp

165-175 °C (dec.) (lit.)

mp

165-175 °C (dec.) (lit.)

mp

165-175 °C (dec.) (lit.)

Application

Isoprenaline hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

β-adrenoceptor agonist; increases cytosolic cAMP.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Christiane Neuber et al.
The Journal of pharmacology and experimental therapeutics, 349(1), 39-46 (2014-01-17)
Stimulation of myocardial β(1)-adrenoceptors (AR) is a major mechanism that increases cardiac function. We investigated the functional consequences of genetic β(1)-AR knockdown in three-dimensional engineered heart tissue (EHT). For β(1)-AR knockdown, short interfering RNA (siRNA) sequences targeting specifically the β(1)-AR
T S Higa et al.
Life sciences, 103(1), 41-48 (2014-03-19)
This study sought to determine the role of white adipose tissue (WAT) metabolism in the prevention of insulin resistance (IR) by physical training (PT). Male C57BL/6J mice were assigned into groups CHOW-SED (chow diet, sedentary; n=15), CHOW-TR (chow diet, trained;
Rishi K Somvanshi et al.
Biochimica et biophysica acta, 1843(4), 735-745 (2014-01-15)
In the present study, we report that somatostatin receptor 2 (SSTR2) plays a crucial role in modulation of β1AR and β2AR mediated signaling pathways that are associated with increased intracellular Ca(2+) and cardiac complications. In H9c2 cells, SSTR2 colocalizes with
Han-Jun Wang et al.
Hypertension (Dallas, Tex. : 1979), 64(4), 745-755 (2014-07-02)
The enhanced cardiac sympathetic afferent reflex (CSAR) contributes to the exaggerated sympathoexcitation in chronic heart failure (CHF). Increased sympathoexcitation is positively related to mortality in patients with CHF. However, the potential beneficial effects of chronic CSAR deletion on cardiac and
Peter Kubuš et al.
Circulation. Arrhythmia and electrophysiology, 7(2), 218-223 (2014-02-04)
Data on the results and clinical effect of an invasive risk stratification strategy in asymptomatic young patients with the Wolff-Parkinson-White electrocardiographic pattern are scarce. Eighty-five consecutive patients aged<18 years with a Wolff-Parkinson-White pattern and persistent preexcitation at maximum exercise undergoing
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