A4352

Anti-phospho-AMPA Receptor, GluR1 Subunit (pSer⁸³¹) antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-phospho-AMPA Glutamate Receptor 1 (pSer⁸³¹)
• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD04040522
• Conjugate: unconjugated
• Clone: polyclonal
• Application: ELISA (d), IHC, IP, WB
• Citations: 7

Properties

• biological source: rabbit
• Quality Segment: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 100 kDa
• species reactivity: rat, human
• concentration: ~1 mg/mL
• technique(s): direct ELISA: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: 1:1,000 using rat brain (hippocampal) homogenate
• UniProt accession no.: P42261
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer831)
• Gene Information: human ... GRIA1(2890) ; rat ... Gria1(50592)

Description

General description

AMPA is a transmembrane receptor for glutamate that regulates synapsis in the central nervous system. It is composed of 4 types of subunits, GluR1, 2, 3, 4.

GluR1 subunits of AMPA receptors are membrane proteins that regulate synaptic plasticity of the central nervous system. This receptor has also been implicated in spatial memory retention. Phosphorylation of serine 831 in GluR1 subunit of the AMPA receptor modulates long-term potentiation in neuronal synapses. Anti-phospho-AMPA Receptor, GluR1 Subunit (pSer⁸³¹) antibody is specific for the GluR1 subunit (phosphorylated on serine 831) of the AMPA receptor in rats and humans.

Immunogen

The GluR1 sequence is conserved among species and has partial homology to VGLUT2.

synthetic phosphopeptide corresponding to a region near serine 831 of rat glutamate receptor subunit GluR1.

Application

Anti-phospho-AMPA Receptor, GluR1 Subunit (pSer⁸³¹) antibody is suitable for use in direct ELISA, immunohistochemistry, immunoblot and immunoprecipitation. The antibody may also be used for western blot (1:1,000 using rat hippocampal homogenate).

Physical form

Solution in 10 mM HEPES buffer, pH 7.5, containing 150 mM NaCl, 100 μg/ml BSA and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable