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BTA-1

Name: BTA-1
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

2-(4´-Methylaminophenyl)benzothiazole

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₂N₂S

CAS Number:

439858-28-3

Molecular Weight:

240.32

NACRES:

NA.77

PubChem Substance ID:

24724428

UNSPSC Code:

12352200

MDL number:

MFCD04974146

Assay:

≥98% (HPLC)

Form:

solid

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

solid

color

yellow

solubility

DMSO: soluble ~10 mg/mL

storage temp.

2-8°C

SMILES string

CNc1ccc(cc1)-c2nc3ccccc3s2

InChI

1S/C14H12N2S/c1-15-11-8-6-10(7-9-11)14-16-12-4-2-3-5-13(12)17-14/h2-9,15H,1H3

InChI key

FHJRKGXJBXPBGA-UHFFFAOYSA-N

Gene Information

human ... APP(351)

Description

Biochem/physiol Actions

BTA-1 is a fluorescent thioflavin-T derivative with 50-fold higher affinity for β-amyloid aggregates.

BTA-1 is a probe for β-amyloid aggregates; fluorescent thioflavin-T derivative; exhibits high affinity for amyloid deposits; displays 50-fold higher affinity than thioflavin-T; selectively stains cerebral plaques and cerebrovascular amyloid deposits in the brains of PS1/APP transgenic mice, as well as Aβ fibrils in postmortem brain tissue obtained from AD patients; crosses the blood brain barrier.

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This Item	F3680	A7232	528283
Sigma-Aldrich B9934 BTA-1	Sigma-Aldrich F3680 10058-F4	Sigma-Aldrich A7232 AP-18	Sigma-Aldrich 528283 Polo-like Kinase Inhibitor II, BTO-1
description ≥98% (HPLC), solid	description ≥98% (HPLC), solid	description ≥98% (HPLC), solid	description The Polo-like Kinase Inhibitor II, BTO-1, also referenced under CAS 40647-02-7, controls the biological activity of Polo-like Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥97% (HPLC)
form solid	form solid	form solid	form solid
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: soluble ~10 mg/mL	solubility DMSO: >10 mg/mL, H₂O: <2 mg/mL	solubility DMSO: >10 mg/mL	solubility DMSO: 1 mg/mL
color yellow	color yellow	color white to off-white	color beige to brown