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S-(−)-Eticlopride hydrochloride

Name: S-(&#8722;)-Eticlopride hydrochloride
Brand: SIGMA

≥98% (HPLC), D2 dopamine receptor antagonist, powder

Synonym(s):

FLB 131, S-(−)-3-Chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxybenzamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₂₅ClN₂O₃ · HCl

CAS Number:

97612-24-3

Molecular Weight:

377.31

UNSPSC Code:

12352200

PubChem Substance ID:

24278428

NACRES:

NA.77

MDL number:

MFCD00055132

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

desiccated

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Properties

Product Name

S-(−)-Eticlopride hydrochloride, ≥98% (HPLC), powder

Quality Segment

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]27/D −7.2°, c = 0.3 in methanol(lit.)

storage condition

desiccated

color

off-white

solubility

H₂O: soluble >10 mg/mL, ethanol: soluble 2.6 mg/mL, 0.1 M HCl: soluble 7 mg/mL

SMILES string

Cl.CCN1CCC[C@H]1CNC(=O)c2c(O)c(CC)cc(Cl)c2OC

InChI

1S/C17H25ClN2O3.ClH/c1-4-11-9-13(18)16(23-3)14(15(11)21)17(22)19-10-12-7-6-8-20(12)5-2;/h9,12,21H,4-8,10H2,1-3H3,(H,19,22);1H/t12-;/m0./s1

InChI key

HFJFXXDHVWLIKX-YDALLXLXSA-N

Gene Information

human ... DRD2(1813)

Description

Application

S-(−)-Eticlopride hydrochloride has been used in astrocyte-neuron coculture and functional magnetic resonance imaging (fMRI) experiments.

Biochem/physiol Actions

Potent and selective D2 dopamine receptor antagonist. Eticlopride is highly specific for DAD2 receptors than pimozide or haloperidol. The gene encoding the D2 dopamine receptor (DRD2) is linked with a several disorders including Parkinson′s disease, schizophrenia, and susceptibility to alcoholism.

Preparation Note

Solutions may be stored at 4° C for several days

Legal Information

Manufactured and sold with the permission of Astra AB.

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This Item	SML1552	L1011	S8010
Sigma-Aldrich E101 S-(−)-Eticlopride hydrochloride	Sigma-Aldrich SML1552 Tipiracil hydrochloride	Sigma-Aldrich L1011 Labetalol hydrochloride	Sigma-Aldrich S8010 (±)-Sulpiride
description ≥98% (HPLC), powder	description ≥98% (HPLC)	description >98% (TLC), powder	description -
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay >98% (TLC)	assay -
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 200	Quality Level 100
solubility ethanol: soluble 2.6 mg/mL, H₂O: soluble >10 mg/mL, 0.1 M HCl: soluble 7 mg/mL	solubility H₂O: 5 mg/mL, clear (warmed)	solubility -	solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL, H₂O: slightly soluble, ethanol: soluble, 0.1 M HCl: soluble
storage condition desiccated	storage condition desiccated	storage condition -	storage condition -
color off-white	color white to beige	color white	color white

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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