F4429

FAUC 213

≥98% (HPLC), solid

• Synonym(s): 2-[4-(4-Chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine
• Empirical Formula (Hill Notation): C₁₈H₁₉ClN₄
• CAS Number: 337972-47-1
• Molecular Weight: 326.82
• NACRES: NA.77
• PubChem Substance ID: 24894864
• UNSPSC Code: 12352200
• MDL number: MFCD06798338
• Assay: ≥98% (HPLC)
• Form: solid

Properties

• assay: ≥98% (HPLC)
• form: solid
• color: white
• solubility: DMSO: ~24 mg/mL (with warming up to 60 °C), H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: Clc1ccc(cc1)N2CCN(CC2)Cc3cc4ccccn4n3
• InChI: 1S/C18H19ClN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)14-16-13-18-3-1-2-8-23(18)20-16/h1-8,13H,9-12,14H2
• InChI key: DTRXURJDKOYCCD-UHFFFAOYSA-N
• Gene Information: human ... DRD2(1813), DRD3(1814), DRD4(1815)

Description

Application

FAUC 213 has been used as a selective dopamine receptor D4-R antagonist:

• to test its effect on the expression of luteinizing hormone in eel pituitary primary cell culture
• to test its effect on bupropion induced hypophagia and locomotion in rats
• to test its modulatory effects on rat basolateral amygdala in the presence of dopamine

Biochem/physiol Actions

FAUC 213 displays antipsychotic properties and may be of use in studies related to behavioral neurobiology and neurochemistry.

Highly selective D₄ dopamine receptor full antagonist

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): dust mask type N95 (US), Eyeshields, Gloves