This product is a further purification of product H3506 and may contain some residual salts, such as sodium chloride.
H3631
Hyaluronidase from bovine testes
Type VI-S, lyophilized powder, 3,000-15,000 units/mg solid
Synonym(s):
Hyaluronate 4-glycanohydrolase, Hyaluronoglucosaminidase
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About This Item
CAS Number:
EC Number:
MDL number:
UNSPSC Code:
12352204
NACRES:
NA.54
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biological source
bovine testis
Quality Level
conjugate
conjugate (Glucosaminoglycan)
type
Type VI-S
form
lyophilized powder
specific activity
3,000-15,000 units/mg solid
mol wt
~55 kDa (four subunits of 14 kDa each)
relevant disease(s)
cancer
storage temp.
−20°C
Gene Information
cow ... HYAL1(515397), HYAL2(281838)
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Biochem/physiol Actions
Hyaluronidase degrades hyaluronan and has been found to be inappropriately regulated during cancer progression.
These enzymes randomly cleave β-N-acetylhexosamine-[1→4] glycosidic bonds in hyaluronic acid, chondroitin, and chondroitin sulfates.
Preparation Note
Chromatographically purified
Other Notes
One unit will degrade 0.75 μg of the polysaccharide hyaluronic acid per minute at pH 5.35 at 37 ºC (as measured by turbidimetric absorbance (λ: 600nm) when complexed with BSA after 45 minutes).
View more information on enzymes for complex carbohydrate analysis at www.sigma-aldrich.com/enzymeexplorer
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Resp. Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Tongcui Ma et al.
eLife, 11 (2022-07-06)
High-parameter single-cell phenotyping has enabled in-depth classification and interrogation of immune cells, but to date has not allowed for glycan characterization. Here, we develop CyTOF-Lec as an approach to simultaneously characterize many protein and glycan features of human immune cells
Dong-Ru Ho et al.
International journal of urology : official journal of the Japanese Urological Association, 18(7), 525-531 (2011-05-25)
To investigate how hyaluronic acid (HA) affects nerve growth factor (NGF) production and bladder overactivity in a cyclophosphamide (CYP)-induced cystitis rat model. Female Sprague-Dawley rats received three intermittent intraperitoneal injections of CYP (75 mg/kg) or saline. Before or after CYP injection
Tongcui Ma et al.
eLife, 9 (2020-05-27)
The female reproductive tract (FRT) is the most common site of infection during HIV transmission to women, but viral remodeling complicates characterization of cells targeted for infection. Here, we report extensive phenotypic analyses of HIV-infected endometrial cells by CyTOF, and
Shared decision making, thrombotic thrombocytopenic purpura, and caplacizumab.
Senthil Sukumar et al.
American journal of hematology, 95(4), E76-E77 (2020-01-03)
Sialic acids rather than glycosaminoglycans affect normal and sickle red blood cell rheology by binding to four major sites on fibrinogen.
Frank Gondelaud et al.
American journal of hematology, 95(4), E77-E80 (2020-01-07)
Related Content
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We bought this product. H3631, Batch Number: SLCH2685. Could you please provide the info on componants like, what are other componants present along with Hyaluronidase which is 3909/mg of solid (40ug, what is the remaining 940ug)?
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