SRE0037
β-Glucuronidase from abalone
aqueous solution, β-glucuronidase ≥100,000 units/mL
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Product Name
β-Glucuronidase from abalone, aqueous solution, β-glucuronidase ≥100,000 units/mL
form
aqueous solution
β-glucuronidase activity
≥100,000 units/mL
secondary activity
≤8,000 units/mL sulfatase
storage temp.
2-8°C
Quality Level
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Related Categories
1 of 4
This Item | SRE0023 | SRE0093 | G0876 |
|---|---|---|---|
| form aqueous solution | form aqueous solution | form aqueous solution | form aqueous solution |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| Quality Level 200 | Quality Level 200 | Quality Level 300 | Quality Level 300 |
| β-glucuronidase activity ≥100,000 units/mL | β-glucuronidase activity ≥20,000,000 units/g protein, 150,000-250,000 units/mL | β-glucuronidase activity - | β-glucuronidase activity - |
| secondary activity ≤8,000 units/mL sulfatase | secondary activity ≤7,500 units/mL sulfatase | secondary activity - | secondary activity ≤7,500 units/mL sulfatase |
Application
Beta-glucuronidase from abalone has been used as a standard to evaluate its performance in benzodiazepine liquid chromatography-mass spectrometry (LC-MS/MS)confirmation assays.[1]
Technical Article Comparing Performance of Different Enzymes
Learn more
about recent application data generated by Sigma R&D to optimize hydrolysis for different drug classes using enzymes from different sources and the use of a chromatographicaly purified enzyme to reduce the effect of esterase activity resulting in conversion of 6-MAM to Morphine.
Learn more
about recent application data generated by Sigma R&D to optimize hydrolysis for different drug classes using enzymes from different sources and the use of a chromatographicaly purified enzyme to reduce the effect of esterase activity resulting in conversion of 6-MAM to Morphine.
Biochem/physiol Actions
Beta-glucuronidase is anenzyme present in several animals, plants, and bacteria. It catalyzes thehydrolysis of Beta-glucuronide conjugates and plant glucuronides.[2]Beta-glucuronidase is a member of the glycosyl hydrolases (GHs) family 2 and is ahomo-tetrameric glycoprotein. [3]It facilitates the removal of glucuronic acidsfrom glucuronides and aids in the liver metabolism enzymes for the excretion ofendo- and xeno-biotics.[4]
Other Notes
One Sigma or modified Fishman unit will liberate 1.0 μg of phenolphthalein from phenolphthalein glucuronide per hr at 37 °C at pH 3.8 (30 min assay).
Physical form
Supplied as an aqueous solution containing 0.85% NaCl and 0.02% sodium azide
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Francesco Candeliere et al.
Frontiers in microbiology, 13, 826994-826994 (2022-03-22)
β-glucuronidases (GUS) of intestinal bacteria remove glucuronic acid from glucoronides, reversing phase II metabolism of the liver and affecting the level of active deconjugated metabolites deriving from drugs or xenobiotics. Two hundred seventy-nine non-redundant GUS sequences are known in the
Miau-Guo Kang et al.
Journal of analytical toxicology, 43(2), 96-103 (2018-10-03)
Benzodiazepines is a large drug group used extensively to treat sleep disorders and anxiety; these drugs are frequently associated with various crimes such as murder and drug-facilitated sexual assault. With growing use and misuse of these compounds, confirmatory assays are
Paul Awolade et al.
European journal of medicinal chemistry, 187, 111921-111921 (2019-12-14)
The emergence of disease and dearth of effective pharmacological agents on most therapeutic fronts, constitutes a major threat to global public health and man's existence. Consequently, this has created an exigency in the search for new drugs with improved clinical
D H Kim et al.
Biological & pharmaceutical bulletin, 22(2), 162-164 (1999-03-17)
To prove the relationship between the fluctuation in serum beta-glucuronidase level and hepatotoxicity, an inhibitor of beta-glucuronidase from G. lucidum was isolated and its hepatoprotective activity was investigated. The ether fraction of G. lucidum, which had potent beta-glucuronidase-inhibitory activity, protected
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