SRP0327
PADI-2 human
recombinant, expressed in baculovirus infected Sf9 cells, ≥60% (SDS-PAGE)
Synonym(s):
Peptidyl arginine deiminase, type II
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About This Item
NACRES:
NA.77
UNSPSC Code:
12352200
Product Name
PADI-2 human, recombinant, expressed in baculovirus infected Sf9 cells, ≥60% (SDS-PAGE)
biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
assay
≥60% (SDS-PAGE)
form
aqueous solution
mol wt
77 kDa
packaging
pkg of 10 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... PADI2(11240)
Application
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. PADI-2 human has been used in in vitro binding assays.
Biochem/physiol Actions
Peptidyl arginine deiminase, protein-2 (PADI2) promotes protein citrullination and represses the multiplication of cells. It helps to transform the amino acid arginine in a protein into amino acid citrulline. PADI2 participates in epigenetic mechanisms. It is linked with rheumatoid arthritis.
General description
Human PADI2, also known as Peptidyl arginine deiminase, type II, (GenBank Accession No. NM_007365), amino acids 1-665 (end) with C-terminal FLAG-tag, MW= 77kDa, expressed in a Baculovirus infected Sf9 cell expression system. Peptidyl arginine deiminase, protein-2 (PADI2) is mapped to human chromosome 1p36. It is expressed in Sertoli cells at the time of testicular development.
Physical form
Formulated in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 80 ng/uL Flag peptide, 3 mMDTT, and 20% Glycerol.
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Peptidyl arginine deiminase 2 (Padi2) is expressed in Sertoli cells in a specific manner and regulated by SOX9 during testicular development
Tsuji-H A, et al.
Scientific Reports, 8 (2018)
Sijun Dong et al.
The Journal of investigative dermatology, 124(5), 1026-1033 (2005-04-28)
Peptidylarginine deiminases (PAD) convert protein-bound arginine residues into citrulline residues in a Ca(2+) ion-dependent manner. Among the five isoforms (PAD1, 2, 3, 4, and 6) existing in rodents and humans, PAD2 is the most widely expressed in both species, tissues
PADI2 is significantly associated with rheumatoid arthritis
Chang X, et al.
Testing, 8(12), e81259-e81259 (2013)
Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system
Musse AA, et al.
Disease models & mechanisms, dmm-000729 (2008)
Peptidyl arginine deiminase 2 (Padi2) is expressed in Sertoli cells in a specific manner and regulated by SOX9 during testicular development
Tsuji-H A, et al.
Scientific reports, 8 (2018)
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