T1145

L-Tyrosine disodium salt hydrate

Name: <SC>L</SC>-Tyrosine disodium salt hydrate
Brand: SIGMA

BioReagent, suitable for cell culture, suitable for insect cell culture, ≥98% (HPLC)

Synonym(s):

L-3-(4-Hydroxyphenyl)alanine disodium salt hydrate

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About This Item

Empirical Formula (Hill Notation):

C₉H₉NNa₂O₃ · xH₂O

CAS Number:

69847-45-6

Molecular Weight:

225.15 (anhydrous basis)

MDL number:

MFCD08276422

UNSPSC Code:

12352209

eCl@ss:

32160406

PubChem Substance ID:

24899937

NACRES:

NA.75

Key Documents

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product line

BioReagent

Quality Level

300

Assay

≥98% (HPLC)

form

powder

technique(s)

cell culture | insect: suitable
cell culture | mammalian: suitable

color

white to beige

storage temp.

2-8°C

SMILES string

O.[Na+].[Na+].N[C@@H](Cc1ccc([O-])cc1)C([O-])=O

InChI

1S/C9H11NO3.2Na.H2O/c10-8(9(12)13)5-6-1-3-7(11)4-2-6;;;/h1-4,8,11H,5,10H2,(H,12,13);;;1H2/q;2*+1;/p-2/t8-;;;/m0.../s1

InChI key

SMJHYQCAVHUILN-CZDIJEQGSA-L

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This Item	T2269	137254	T8566
Sigma-Aldrich T1145 L-Tyrosine disodium salt hydrate	Sigma-Aldrich T2269 L-Tyrosine disodium salt hydrate	SAFC 137254 L-Tyrosine disodium salt dihydrate	Sigma-Aldrich T8566 L-Tyrosine
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay -	assay 99.0-101.0%
technique(s) cell culture \| insect: suitable, cell culture \| mammalian: suitable	technique(s) -	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
product line BioReagent	product line -	product line EMPROVE^® EVOLVE	product line BioXtra
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-30°C	storage temp. room temp
Quality Level 300	Quality Level 200	Quality Level 400	Quality Level 300

General description

Tyrosine is a polar, non-essential amino acid with a phenolic functionality. L-tyrosine is a natural amino acid that is incorporated into proteins as directed by the genetic code. The phenolic function makes the tyrosine residue in proteins a principle recipient of reactions such as phosphorylation/dephosphorylation important for cell signalling. Tyrosine is also a precursor of various neurotransmitters and hormones.

Application

This product has been qualified for use in insect cell cultures.

Other Notes

Amino acid precursor of dopamine and other catecholamines

Disclaimer

Extremely hygroscopic.

Pictograms

GHS05

Signal Word

Danger

Hazard Statements

H318

Precautionary Statements

P280 - P305 + P351 + P338

Hazard Classifications

Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Asparagine enhances LCK signalling to potentiate CD8+ T-cell activation and anti-tumour responses.

Jun Wu et al.

Nature cell biology, 23(1), 75-86 (2021-01-10)

Nutrient availability is central for T-cell functions and immune responses. Here we report that CD8+ T-cell activation and anti-tumour responses are strongly potentiated by the non-essential amino acid Asn. Increased Asn levels enhance CD8+ T-cell activation and effector functions against

Subcutaneous L-tyrosine elicits cutaneous analgesia in response to local skin pinprick in rats.

Ching-Hsia Hung et al.

European journal of pharmacology, 765, 457-462 (2015-09-17)

The purpose of the study was to estimate the ability of L-tyrosine to induce cutaneous analgesia and to investigate the interaction between L-tyrosine and the local anesthetic lidocaine. After subcutaneously injecting the rats with L-tyrosine and lidocaine in a dose-dependent

Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis.

Zihao Wang et al.

Science signaling, 3(104), ra2-ra2 (2010-01-14)

Like phosphorylation, the addition of O-linked beta-N-acetylglucosamine (O-GlcNAcylation) is a ubiquitous, reversible process that modifies serine and threonine residues on nuclear and cytoplasmic proteins. Overexpression of the enzyme that adds O-GlcNAc to target proteins, O-GlcNAc transferase (OGT), perturbs cytokinesis and

Amino acids inhibit kynurenic acid formation via suppression of kynurenine uptake or kynurenic acid synthesis in rat brain in vitro.

Airi Sekine et al.

SpringerPlus, 4, 48-48 (2015-02-13)

The tryptophan metabolite, kynurenic acid (KYNA), is a preferential antagonist of the α7 nicotinic acetylcholine receptor at endogenous brain concentrations. Recent studies have suggested that increase of brain KYNA levels is involved in psychiatric disorders such as schizophrenia and depression.

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