H6167

Cholesterol

Name: Cholesterol
Brand: SIGMA

from sheep wool, Controlled origin, meets USP/NF testing specifications

Synonym(s):

3β-Hydroxy-5-cholestene, 5-Cholesten-3β-ol

Slide 1 of 1

Select a Size

Pricing and availability is not currently available.

About This Item

Empirical Formula (Hill Notation):

C₂₇H₄₆O

CAS Number:

57-88-5

Molecular Weight:

386.65

Beilstein:

1915888

EC Number:

200-353-2

MDL number:

MFCD00003646

UNSPSC Code:

12352211

PubChem Substance ID:

329815229

NACRES:

NA.21

Key Documents

View All Documentation

biological source

sheep wool

Quality Level

300

Agency

meets USP/NF testing specifications

form

powder

origin

Australia origin
New Zealand origin

bp

360 °C (lit.)

mp

147-149 °C (lit.)

solubility

water: soluble 0.00003 g/L at 20 °C

density

1.067 g/mL at 25 °C (lit.)

SMILES string

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

InChI key

HVYWMOMLDIMFJA-DPAQBDIFSA-N

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item	PHR1533	C3045	26732
SAFC H6167 Cholesterol	Supelco PHR1533 Cholesterol	Sigma-Aldrich C3045 Cholesterol	Sigma-Aldrich 26732 Cholesterol
agency meets USP/NF testing specifications	agency traceable to Ph. Eur. C2155000, traceable to USP 1131960	agency -	agency -
form powder	form powder	form powder	form powder
density 1.067 g/mL at 25 °C (lit.)	density 1.067 g/mL at 25 °C (lit.)	density 1.067 g/mL at 25 °C (lit.)	density 1.067 g/mL at 25 °C (lit.)
solubility water: soluble 0.00003 g/L at 20 °C	solubility water: soluble 0.00003 g/L at 20 °C	solubility H₂O: 0.002 mg/mL, Tween: soluble, ethanol: soluble, serum: soluble	solubility chloroform: 0.1 g/mL, clear, colorless
biological source sheep wool	biological source -	biological source ovine wool	biological source lanolin
origin Australia origin	origin -	origin -	origin -

General description

Our SAFC^® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.

Biochem/physiol Actions

Major component of all biological membranes; ~25% of total brain lipid is cholesterol.

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation.

Jinjiang Fan et al.

Proceedings of the National Academy of Sciences of the United States of America, 112(23), 7261-7266 (2015-06-04)

Translocator protein (TSPO) is a key member of the mitochondrial cholesterol transport complex in steroidogenic tissues. To assess the function of TSPO, we generated two lines of Cre-mediated Tspo conditional knockout (cKO) mice. First, gonadal somatic cell-targeting Amhr2-Cre mice were

Effects of the pure flavonoids epicatechin and quercetin on vascular function and cardiometabolic health: a randomized, double-blind, placebo-controlled, crossover trial.

James I Dower et al.

The American journal of clinical nutrition, 101(5), 914-921 (2015-05-03)

Prospective cohort studies showed inverse associations between the intake of flavonoid-rich foods (cocoa and tea) and cardiovascular disease (CVD). Intervention studies showed protective effects on intermediate markers of CVD. This may be due to the protective effects of the flavonoids

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.

Daniel I Swerdlow et al.

Lancet (London, England), 385(9965), 351-361 (2014-09-30)

Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target. We used single nucleotide polymorphisms in the HMGCR

PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial.

Frederick J Raal et al.

Lancet (London, England), 385(9965), 331-340 (2014-10-06)

Heterozygous familial hypercholesterolaemia is characterised by low cellular uptake of LDL cholesterol, increased plasma LDL cholesterol concentrations, and premature cardiovascular disease. Despite intensive statin therapy, with or without ezetimibe, many patients are unable to achieve recommended target levels of LDL

Genetic ablation of macrohistone H2A1 leads to increased leanness, glucose tolerance and energy expenditure in mice fed a high-fat diet.

F Sheedfar et al.

International journal of obesity (2005), 39(2), 331-338 (2014-05-23)

In the context of obesity, epigenetic mechanisms regulate cell-specific chromatin plasticity, perpetuating gene expression responses to nutrient excess. MacroH2A1, a variant of histone H2A, emerged as a key chromatin regulator sensing small nutrients during cell proliferation and differentiation. Mice genetically

View All Related Papers

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service