The product is tested for purity by SDS-PAGE, according to the certificate of analysis. However, this product has not been tested in-house for suitability in native gel electrophoresis.
M1891
Myelin Basic Protein bovine
≥90% (SDS-PAGE), lyophilized powder, suitable for activity assay
Synonym(s):
MBP
Sign In to View Organizational & Contract Pricing
Select a Size
Pricing and availability is not currently available.
About This Item
Skip To
biological source
bovine
Quality Level
Assay
≥90% (SDS-PAGE)
form
lyophilized powder
mol wt
18.4 kDa
storage condition
(Keep container tightly closed in a dry and well-ventilated place)
technique(s)
activity assay: suitable
solubility
water: 1 mg/mL, clear, colorless to faintly yellow
UniProt accession no.
storage temp.
−20°C
Gene Information
cow ... MBP(618684)
1 of 4
This Item | M3755 | M2295 | M0689 |
|---|---|---|---|
| biological source bovine | biological source - | biological source guinea pig brain | biological source human brain |
| technique(s) activity assay: suitable | technique(s) - | technique(s) cell based assay: suitable | technique(s) ELISA: suitable |
| assay ≥90% (SDS-PAGE) | assay ≥97% (HPLC) | assay ≥80% (SDS-PAGE) | assay ≥95% (SDS-PAGE) |
| mol wt 18.4 kDa | mol wt - | mol wt - | mol wt - |
| form lyophilized powder | form - | form lyophilized powder | form lyophilized powder |
| storage condition (Keep container tightly closed in a dry and well-ventilated place) | storage condition - | storage condition - | storage condition - |
General description
Research Area: Cell Signaling
Myelin basic protein (MBP), a single-chain polypeptide consisting of 170 amino acids[1] with a methyl-arginine, is a peripheral membrane protein.[2] This crucial structural component of the myelin sheath is the second-most abundant protein in myelin representing about 30% of the total myelin protein.[3]
Myelin basic protein (MBP), a single-chain polypeptide consisting of 170 amino acids[1] with a methyl-arginine, is a peripheral membrane protein.[2] This crucial structural component of the myelin sheath is the second-most abundant protein in myelin representing about 30% of the total myelin protein.[3]
Application
Myelin Basic Protein (MBP) bovine has been used:
Used as a kinase substrate.
Biochem/physiol Actions
Mutation of the myelin basic protein gene induces dysmyelination. It is used to induce experimental allergic encephalomyelitis.
Myelin basic protein (MBP) plays a vital role in the formation of the myelin sheath and is associated with various neurological disorders. MBP functions as an antigenic target in the autoimmune disease experimental allergic encephalomyelitis (EAE). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositide, and regulation of calcium homoeostasis.[8] MBP functions as an in vitro substrate for mitogen-activated protein kinase (MAP) kinase and aids in the purification and functional studies of enzymes.[9]MBP serves as a potential neuroreceptor. It can stimulate the proliferation of lymphocytes in vitro. MBP plays a key role as a substrate in the mitogen-activated protein (MAP) kinase activation pathway.[10] Based on lymphocyte stimulation, MBP can be used to detect cancer. It is used in several immunological studies. MBP also contributes to the preservation of the lipid: protein organization within myelin.[2]
Analysis Note
May contain traces of urea-glycine buffer salts.
related product
Product No.
Description
Pricing
used together
Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Michal Jasinski et al.
Plant physiology, 147(2), 719-731 (2008-04-09)
The analysis of gene expression in Arabidopsis (Arabidopsis thaliana) using cDNA microarrays and reverse transcription-polymerase chain reaction showed that AtOSA1 (A. thaliana oxidative stress-related Abc1-like protein) transcript levels are influenced by Cd2+ treatment. The comparison of protein sequences revealed that
Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain.
Sayegh J
The Journal of Biological Chemistry, 282(50), 36444-36453 (2007)
C Delehouzé et al.
Scientific reports, 7(1), 12931-12931 (2017-10-12)
Necroptosis is a programmed cell death pathway that has been shown to be of central pathophysiological relevance in multiple disorders (hepatitis, brain and cardiac ischemia, pancreatitis, viral infection and inflammatory diseases). Necroptosis is driven by two serine threonine kinases, RIPK1
Hsl7 is a substrate-specific type II protein arginine methyltransferase in yeast.
Sayegh J and Clarke SG
Biochemical and Biophysical Research Communications, 372(4), 811-815 (2008)
Chuan-Ming Yeh et al.
Plant & cell physiology, 45(9), 1306-1312 (2004-10-29)
Mitogen-activated protein kinase (MAPK) pathways are modules involved in the transduction of extracellular signals to intracellular targets in all eukaryotes. In plants, it has been evidenced that MAPKs play a role in the signaling of biotic and abiotic stresses, plant
Related Content
Product Information Sheet
-
Please answer.Is suitable for native gel electrophoresis Myelin basic protein bovine sds-page from merck using native PAGE sample buffer: 5-10% glycerol 0.01% bromophenol blue Thanks
1 answer-
Helpful?
-
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service