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Streptococcus pneumoniae arginine synthesis genes promote growth and virulence in pneumococcal meningitis.

The Journal of infectious diseases (2013-12-18)
Jurgen R Piet, Madelijn Geldhoff, Barbera D C van Schaik, Matthijs C Brouwer, Mercedes Valls Seron, Marja E Jakobs, Kim Schipper, Yvonne Pannekoek, Aeilko H Zwinderman, Tom van der Poll, Antoine H C van Kampen, Frank Baas, Arie van der Ende, Diederik van de Beek
ABSTRACT

Streptococcus pneumoniae (pneumococcus) is a major human pathogen causing pneumonia, sepsis and bacterial meningitis. Using a clinical phenotype based approach with bacterial whole-genome sequencing we identified pneumococcal arginine biosynthesis genes to be associated with outcome in patients with pneumococcal meningitis. Pneumococci harboring these genes show increased growth in human blood and cerebrospinal fluid (CSF). Mouse models of meningitis and pneumonia showed that pneumococcal strains without arginine biosynthesis genes were attenuated in growth or cleared, from lung, blood and CSF. Thus, S. pneumoniae arginine synthesis genes promote growth and virulence in invasive pneumococcal disease.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
DL-Arginine, ≥95% (NT)
Arginine, European Pharmacopoeia (EP) Reference Standard