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880135P

Avanti

DSPE-PEG(2000) Carboxylic Acid

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000] (sodium salt)

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10 MG

RM 918.00

25 MG

RM 1,338.00

50 MG

RM 1,890.00

100 MG

RM 3,312.00

500 MG

RM 12,792.00

RM 918.00

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About This Item

Empirical Formula (Hill Notation):
C131H257NNaO55P
CAS Number:
1403744-37-5
Molecular Weight:
2780.38
UNSPSC Code:
12352211
NACRES:
NA.25

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Product Name

DSPE-PEG(2000) Carboxylic Acid, Avanti Research™ - A Croda Brand 880135P, powder

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (880135P-10mg)
pkg of 1 × 100 mg (880135P-100mg)
pkg of 1 × 25 mg (880135P-25mg)
pkg of 1 × 50 mg (880135P-50mg)
pkg of 1 × 500 mg (880135P-500mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 880135P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCCNC(C/C=C\OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOCCOOCC(O)=O)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=

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DSPE-PEG(2000) Carboxylic Acid Avanti Research™ - A Croda Brand 880135P, powder

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DSPE-PEG(2000)-square Avanti Research™ - A Croda Brand (880136P), powder

Avanti

880136P

DSPE-PEG(2000)-square

manufacturer/tradename

Avanti Research™ - A Croda Brand 880135P

manufacturer/tradename

Avanti Research™ - A Croda Brand

manufacturer/tradename

Avanti Research™ - A Croda Brand

manufacturer/tradename

Avanti Research™ - A Croda Brand (880136P)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

packaging

pkg of 1 × 10 mg (880135P-10mg), pkg of 1 × 25 mg (880135P-25mg), pkg of 1 × 500 mg (880135P-500mg), pkg of 1 × 50 mg (880135P-50mg), pkg of 1 × 100 mg (880135P-100mg)

packaging

pkg of 1 × 10 mg (880229P-10mg), pkg of 1 × 100 mg (880229P-100mg), pkg of 1 × 25 mg (880229P-25mg), pkg of 1 × 50 mg (880229P-50mg)

packaging

pkg of 1 × 10 mg (880128P-10mg), pkg of 1 × 100 mg (880128P-100mg), pkg of 1 × 25 mg (880128P-25mg), pkg of 1 × 50 mg (880128P-50mg), pkg of 1 × 500 mg (880128P-500mg)

packaging

pkg of 1 × 10 mg (880136P-10mg), pkg of 1 × 25 mg (880136P-25mg)

form

powder

form

powder

form

powder

form

powder

General description

Carboxylic acids are readily soluble in polar solvents such as water and alcohols.[1] DSPE-PEG(2000) carboxylic acid consists of a hydrophilic polyethylene glycol (PEG) chain of 2kDa.[2]

Application

DSPE-PEG(2000) carboxylic acid has been used:
  • to covalently conjugate integrin α-2 (ITGA2) antibodies to the surface of the liposomes[2]
  • in the preparation of atosiban-conjugated liposomes[3]
  • to prepare dual complementary liposome[4]

Biochem/physiol Actions

DSPE-PEG(2000) carboxylic acid increases the blood circulation time of liposomes. The carboxyl group of DSPE-PEG(2000) carboxylic acid aids in covalent conjugation with antibodies.[2]

Packaging

20 mL Clear Glass Screw Cap Vial (880135P-500mg)
5 mL Amber Glass Screw Cap Vial (880135P-100mg)
5 mL Amber Glass Screw Cap Vial (880135P-10mg)
5 mL Amber Glass Screw Cap Vial (880135P-25mg)
5 mL Amber Glass Screw Cap Vial (880135P-50mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

No data available

Flash Point(C)

No data available

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Junxue An et al.
Journal of colloid and interface science, 577, 92-100 (2020-05-31)
Phospholipids constitute biocompatible and safe excipients for pulmonary drug delivery. They can retard the drug release and, when PEGylated, also prolong the residence time in the lung. The aim of this work was to assess the structure and coherence of
Feifei Yang et al.
Small (Weinheim an der Bergstrasse, Germany), 16(7), e1906360-e1906360 (2020-01-24)
Hepatotoxicity is a key concern in the clinical translation of nanotherapeutics because preclinical studies have consistently shown that nanotherapeutics accumulates extensively in the liver. However, clinical-stage nanotherapeutics have not shown increased hepatotoxicity. Factors that can contribute to the hepatotoxicity of
Mohammad Mashreghi et al.
Nanoscale research letters, 15(1), 101-101 (2020-05-10)
In this study, we have surface-functionalized PEGylated-nanoliposomal doxorubicin (DOX) with anti-EpCAM (epithelial cell adhesion molecule) aptamer via post-insertion of anti-EpCAM aptamer-conjugated DSPE-mPEG2000 into Caelyx® (ED-lip). The size, charge, release profile, and cytotoxicity and cellular uptake of formulation were determined. The
Carboxylic Acid: Key Role in Life Sciences (2019)
ITGA2 as a potential nanotherapeutic target for glioblastoma
Guo P, et al.
Scientific reports, 9(1), 6195-6195 (2019)
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