06-342

Anti-JAK3 Antibody

Name: Anti-JAK3 Antibody
Brand: MM

serum, Upstate^®

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse

manufacturer/tradename

Upstate^®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NM_000215

UniProt accession no.

P52333

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

mouse ... Jak3(16453)

General description

125 kDa

Immunogen

peptide corresponding to residues 934-952 (RDELCVAGAQLYACQDPAI) of murine JAK3. The immunizing peptide sequence shares 16/19 amino acids with rat JAK3, but contains an amino acid insertion, which may block cross-reactivity. The immunizing peptide shares 12/19 amino acids with human JAK3.

Application

Anti-JAK3 Antibody is an antibody against JAK3 for use in WB.

Biochem/physiol Actions

: Recognizes murine JAK3, Mr 125kDa and JAK3 degradation products, Mr 95-120kDa. The antiserum shows very poor immunoreactivity for human JAK3. No immunoreaction was noted with immuno-precipitated mouse JAK1 and JAK2

This antibody has been tested on several human cell lines including A431, Hela, Jurkat, and HEK293 cells. The antiserum shows very poor immunoreactivity for human JAK3

Physical form

antiserum containing 0.05% sodium azide

Preparation Note

2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery, centrifuge the original vial after thawing and prior to removing the cap.

Analysis Note

routinely evaluated by immunoblot on lysate from a mouse cytotoxic T lymphocyte cell line (CTLL)

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Certificates of Analysis (COA)

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Differential requirement of the cytoplasmic subregions of gamma c chain in T cell development and function.

Tsujino, S; Di Santo, JP; Takaoka, A; McKernan, TL; Noguchi, S; Taya, C; Yonekawa et al.

Proceedings of the National Academy of Sciences of the USA null

Jak1 expression is required for mediating interleukin-4-induced tyrosine phosphorylation of insulin receptor substrate and Stat6 signaling molecules.

Chen, X H, et al.

The Journal of Biological Chemistry, 272, 6556-6560 (1997)

Synthesis of bioactive (1→6)-β-glucose branched poly-amido-saccharides that stimulate and induce M1 polarization in macrophages.

Ruiqing Xiao et al.

Nature communications, 13(1), 4661-4661 (2022-08-10)

β-Glucans are of significant interest due to their potent antitumor and immunomodulatory activities. Nevertheless, the difficulty in purification, structural heterogenicity, and limited solubility impede the development of structure-property relationships and translation to therapeutic applications. Here, we report the synthesis of

IL-4 and IL-13 activate the JAK2 tyrosine kinase and Stat6 in cultured human vascular endothelial cells through a common pathway that does not involve the gamma c chain.

R L Palmer-Crocker et al.

The Journal of clinical investigation, 98(3), 604-609 (1996-08-01)

IL-4 and IL-13 each act on human endothelial cells (ECs) to induce expression of vascular cell adhesion molecule-1. On hematopoietic cells. IL-4 responses may be mediated either through a pathway involving gc, the common signaling subunit of the IL-2, IL-4

Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation

Yu, C. L. and Burakoff, S. J.

The Journal of Biological Chemistry, 272, 14017-14020 (1997)

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