Diffusible signal factor (cis-11-methyl-2-dodecenoic acid, DSF) is used to study cell-cell communication by pathogenic bacteria such as Xanthomonas campestris pv. Campestris (Xcc). DSF is involved in the synchronization of virulence gene expression and biofilm dispersal.
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With new strains of Acinetobacter baumannii undergoing genomic analysis, it has been possible to define regions of genomic plasticity (RGPs), encoding specific adaptive elements. For a selected RGP from a community-derived isolate of A. baumannii, we outline sequences compatible with
Toxicology in vitro : an international journal published in association with BIBRA, 38, 150-158 (2016-09-25)
Knowledge of how an in vitro aerosol exposure system delivers a test aerosols to the biological test system is among the most crucial prerequisites for the interpretation of exposure experiments and relies on detailed exposure system characterization. Although various methods
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 97, 151-157 (2016-11-21)
Solvents used for therapeutic proteins in downstream processing and in formulations often contain stabilizing additives that inhibit denaturation and aggregation. Such additives are mostly selected based on their positive effect on thermal stability of the protein, and are often derived
Nature chemical biology, 14(6), 542-547 (2018-04-25)
The emergence of enzymes through the neofunctionalization of noncatalytic proteins is ultimately responsible for the extraordinary range of biological catalysts observed in nature. Although the evolution of some enzymes from binding proteins can be inferred by homology, we have a
Nucleic acid triplexes may regulate many important biological processes. Persistent accumulation of the oncogenic 7-kb long noncoding RNA MALAT1 is dependent on an unusually long intramolecular triple helix. This triplex structure is positioned within a conserved ENE (element for nuclear
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