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Merck

C7971

Cilostamide

≥97% (HPLC), PDE3 inhibitor, powder

Synonym(s):

6-[3-(N-Cyclohexyl-N-methylcarbamoyl)propoxy]quinolin-2[1H]-one, OPC 3689

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5 MG

RM 2,643.00

RM 2,643.00

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About This Item

Empirical Formula (Hill Notation):
C20H26N2O3
CAS Number:
68550-75-4
Molecular Weight:
342.43
UNSPSC Code:
12352202
PubChem Substance ID:
24278337
NACRES:
NA.77
MDL number:
MFCD00673958

Key Documents

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Product Name

Cilostamide, phosphodiesterase inhibitor

SMILES string

CN(C1CCCCC1)C(=O)CCCOc2ccc3NC(=O)C=Cc3c2

InChI

1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)

InChI key

UIAYVIIHMORPSJ-UHFFFAOYSA-N

assay

≥97% (HPLC)

form

powder

solubility

DMSO: 20 mg/mL, clear, colorless to faintly yellow

Quality Level

100

Gene Information

human ... PDE3A(5139), PDE3B(5140), PDE5A(8654), PDE7A(5150)
rat ... Pde2a(81743), Pde4a(25638)

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1 of 4

This Item
WH0005139M1EHU141791EMU032201
Cilostamide phosphodiesterase inhibitor

Sigma-Aldrich

C7971

Cilostamide

Monoclonal Anti-PDE3A antibody produced in mouse clone 5C12, purified immunoglobulin, buffered aqueous solution

Sigma-Aldrich

WH0005139M1

Monoclonal Anti-PDE3A antibody produced in mouse

MISSION® esiRNA targeting human PDE7A

Sigma-Aldrich

EHU141791

MISSION® esiRNA

MISSION® esiRNA targeting mouse Pde3a

Sigma-Aldrich

EMU032201

MISSION® esiRNA

assay

≥97% (HPLC)

assay

-

assay

-

assay

-

Gene Information

human ... PDE3A(5139), PDE3B(5140), PDE5A(8654), PDE7A(5150)
rat ... Pde2a(81743), Pde4a(25638)

Gene Information

human ... PDE3A(5139)

Gene Information

human ... PDE7A(5150), PDE7A(5150)

Gene Information

mouse ... PDE3A(54611), Pde3a(54611)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

form

powder

form

buffered aqueous solution

form

lyophilized powder

form

lyophilized powder

solubility

DMSO: 20 mg/mL, clear, colorless to faintly yellow

solubility

-

solubility

-

solubility

-

Biochem/physiol Actions

PDE3 catalyzes the phosphodiester bond hydrolysis, observed in secondory messengers such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Inhibitors of PDE3 are generally inotropic and vasodilatory. They are being recognized for its use in treating heart failures.[1] Cilostamide is known to delay meiotic progression.[2]
Selective cGMP-inhibited phosphodiesterase inhibitor (PDE3); IC50 = 70 ± 9 nM.
Selective inhibitor of PDE3 (cGMP-inhibited phosphodiesterase); IC50 = 70 ± 9 nM. This inhibitory effect increases intracellular cAMP and inhibits platelet aggregation.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ7413
MKCP1197
MKCM7956
MKCL9528
MKCL2541

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Byung Chul Jee et al.
Fertility and sterility, 91(5 Suppl), 2037-2042 (2008-06-17)
To investigate the effect of a phosphodiesterase type 3 inhibitor in oocyte maturation medium on subsequent embryo development. Animal study. University laboratory. CD-1 mice. Immature oocytes were arrested meiotically in medium containing a specific phosphodiesterase type 3 inhibitor, cilostamide (1
Effects of cilostamide and forskolin on the meiotic resumption and embryonic development of immature human oocytes
Shu Y, et al.
Human Reproduction, 23(3), 504-513 (2008)
Xiaofei Zhu et al.
BMC urology, 17(1), 54-54 (2017-07-09)
It has been shown that hosphodiesterases (PDEs) play an important role in mediating the smooth muscle tone of rat urinary bladder. However, the gene expression profiles of them were still unknown. Urinary bladder Strips were obtained from both neonatal and
F K Albuz et al.
Human reproduction (Oxford, England), 25(12), 2999-3011 (2010-09-28)
Oocyte in vitro maturation (IVM) reduces the need for gonadotrophin-induced ovarian hyperstimulation and its associated health risks but the unacceptably low conception/pregnancy rates have limited its clinical uptake. We report the development of a novel in vitro simulated physiological oocyte
Targeting tumor cells based on Phosphodiesterase 3A expression
Nazir M, et al.
Experimental Cell Research, 361(2), 308-315 (2017)
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