O9504

Oxaloacetic acid

Name: Oxaloacetic acid
Brand: SIGMA
Price: 886 MYR

powder, suitable for hybridoma

Synonym(s):

2-Oxosuccinic acid, Ketosuccinic acid, Oxalacetic acid, Oxobutanedioic acid

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O9504-5G

RM 886.00

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About This Item

Linear Formula:

HOOCCH₂COCOOH

CAS Number:

328-42-7

Molecular Weight:

132.07

Beilstein:

1705475

EC Number:

206-329-8

MDL number:

MFCD00002592

UNSPSC Code:

12352205

PubChem Substance ID:

24898071

NACRES:

NA.75

Key Documents

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Assay

≥97% (HPLC)

Quality Level

200

form

powder

technique(s)

cell culture | hybridoma: suitable

impurities

endotoxin, tested

solubility

H₂O: 100 mg/mL

storage temp.

−20°C

SMILES string

OC(=O)CC(=O)C(O)=O

InChI

1S/C4H4O5/c5-2(4(8)9)1-3(6)7/h1H2,(H,6,7)(H,8,9)

InChI key

KHPXUQMNIQBQEV-UHFFFAOYSA-N

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This Item	O7753	O4126	P3662
Sigma-Aldrich O9504 Oxaloacetic acid	Sigma-Aldrich O7753 Oxaloacetic acid	Sigma-Aldrich O4126 Oxaloacetic acid	Sigma-Aldrich P3662 Sodium pyruvate
assay ≥97% (HPLC)	assay ≥97% (HPLC)	assay ≥97% (HPLC)	assay ≥99%
technique(s) cell culture \| hybridoma: suitable	technique(s) cell culture \| insect: suitable, cell culture \| mammalian: suitable	technique(s) -	technique(s) cell culture \| hybridoma: suitable
solubility H₂O: 100 mg/mL	solubility H₂O: 100 mg/mL	solubility H₂O: 100 mg/mL, clear to slightly hazy, colorless to light yellow	solubility H₂O: 100 mg/mL
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
form powder	form powder	form powder	form powder
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C

Application

Use as a TCA (Krebs cycle) intermediate supplement in hybridoma cell culture applications. Enhances hybridoma growth and productivity.

related product

Product No.

Description

Pricing

O7753

Oxaloacetic acid, powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥97% (HPLC)

Pictograms

GHS07

Signal Word

Warning

Hazard Statements

H319

Precautionary Statements

P264 - P280 - P305 + P351 + P338 - P337 + P313

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

0000501417

0000366662

0000308464

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Effect of glutamate and blood glutamate scavengers oxaloacetate and pyruvate on neurological outcome and pathohistology of the hippocampus after traumatic brain injury in rats.

Alexander Zlotnik et al.

Anesthesiology, 116(1), 73-83 (2011-12-02)

Decreasing blood glutamate concentrations after traumatic brain injury accelerates brain-to-blood glutamate efflux, leading to improved neurologic outcomes. The authors hypothesize that treatment with blood glutamate scavengers should reduce neuronal cell loss, whereas administration of glutamate should worsen outcomes. The authors

Novel insights into the biotin carboxylase domain reactions of pyruvate carboxylase from Rhizobium etli.

Tonya N Zeczycki et al.

Biochemistry, 50(45), 9724-9737 (2011-10-01)

The catalytic mechanism of the MgATP-dependent carboxylation of biotin in the biotin carboxylase domain of pyruvate carboxylase from R. etli (RePC) is common to the biotin-dependent carboxylases. The current site-directed mutagenesis study has clarified the catalytic functions of several residues

Biochemical and histologic pathology in an infant with cross-reacting material (negative) pyruvate carboxylase deficiency.

L T Wong et al.

Pediatric research, 20(3), 274-279 (1986-03-01)

An infant with the acute neonatal form of pyruvate carboxylase deficiency (cross-reacting material negative) presented with severe intractable lactic acidosis within 4 h after birth. He also had hyperammonemia, hypercitrullinemia, and hyperlysinemia. Plasma glutamine was not elevated. He had a

Mitochondrial fission in endothelial cells after simulated ischemia/reperfusion: role of nitric oxide and reactive oxygen species.

Randy J Giedt et al.

Free radical biology & medicine, 52(2), 348-356 (2011-11-22)

Ischemia (I)/reperfusion (RP)-induced endothelial cell (EC) injury is thought to be due to mitochondrial reactive oxygen species (mtROS) production. MtROS have been implicated in mitochondrial fission. We determined whether cultured EC exposure to simulated I/RP causes morphological changes in the

Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice.

Randy Strong et al.

The journals of gerontology. Series A, Biological sciences and medical sciences, 68(1), 6-16 (2012-03-28)

The National Institute on Aging Interventions Testing Program (ITP) was established to evaluate agents that are hypothesized to increase life span and/or health span in genetically heterogeneous mice. Each compound is tested in parallel at three test sites. It is

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