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Merck

Synthesis of stable isotope labeled 3-acetyldeoxynivalenol.

Molecular nutrition & food research (2005-10-18)
Michael Bretz, Marita Beyer, Benedikt Cramer, Hans-Ulrich Humpf
PMID16229052
ABSTRACT

Stable isotope labeled 3-acetyldeoxynivalenol (3-AcDON) was synthesized in excellent yield from deoxynivalenol as starting material. This is the first synthesis of a stable isotope labeled type-B trichothecene suitable as internal standard for HPLC-MS/MS or GC-MS analysis of trichothecene mycotoxins. The isotopic purity of the 3-d(3)-AcDON was determined to be 94.9%.

MATERIALS
Product Number
Brand
Product Description
A6166
Sigma-Aldrich
3-Acetyldeoxynivalenol, from Fusarium roseum
32927
Supelco
3-Acetyldeoxynivalenol
34132
Supelco
3-Acetyldeoxynivalenol solution, ~100 μg/mL in acetonitrile, analytical standard